Infection-associated thymic atrophy

M Luo, L Xu, Z Qian, X Sun - Frontiers in immunology, 2021 - frontiersin.org
The thymus is a vital organ of the immune system that plays an essential role in thymocyte
development and maturation. Thymic atrophy occurs with age (physiological thymic atrophy) …

Thymic atrophy: experimental studies and therapeutic interventions

S Majumdar, D Nandi - Scandinavian journal of immunology, 2018 - Wiley Online Library
The thymus is essential for T cell development and maturation. It is extremely sensitive to
atrophy, wherein loss in cellularity of the thymus and/or disruption of the thymic architecture …

Delivery of LLKKK18 loaded into self-assembling hyaluronic acid nanogel for tuberculosis treatment

JP Silva, C Gonçalves, C Costa, J Sousa… - Journal of Controlled …, 2016 - Elsevier
Tuberculosis (TB), a disease caused by the human pathogen Mycobacterium tuberculosis,
recently joined HIV/AIDS on the top rank of deadliest infectious diseases. Low patient …

Thymus, undernutrition, and infection: approaching cellular and molecular interactions

W Savino, J Durães, C Maldonado-Galdeano… - Frontiers in …, 2022 - frontiersin.org
Undernutrition remains a major issue in global health. Low protein-energy consumption,
results in stunting, wasting and/or underweight, three deleterious forms of malnutrition that …

Tolerance has its limits: how the thymus copes with infection

C Nunes-Alves, C Nobrega, SM Behar… - Trends in …, 2013 - cell.com
The thymus is required for T cell differentiation; a process that depends on which antigens
are encountered by thymocytes, the environment surrounding the differentiating cells, and …

Protoplast Isolation and Shoot Regeneration from Protoplast-Derived Callus of Petunia hybrida Cv. Mirage Rose

HH Kang, AH Naing, CK Kim - Biology, 2020 - mdpi.com
Despite the increasing use of protoplasts in plant biotechnology research, shoot
regeneration from protoplasts remains challenging. In this study, we investigated the factors …

Bezlotoxumab prevents extraintestinal organ damage induced by Clostridioides difficile infection

SJ Mileto, ML Hutton, SL Walton, A Das… - Gut …, 2022 - Taylor & Francis
Clostridioides difficile is the most common cause of infectious antibiotic-associated diarrhea,
with disease mediated by two major toxins TcdA and TcdB. In severe cases, systemic …

Severe influenza A (H1N1) pdm09 infection induces thymic atrophy through activating innate CD8+ CD44hi T cells by upregulating IFN-γ

B Liu, X Zhang, W Deng, J Liu, H Li, M Wen… - Cell Death & …, 2014 - nature.com
Thymic atrophy has been described as a consequence of infection by several pathogens
including highly pathogenic avian influenza virus and is induced through diverse …

Acute thymic involution and mechanisms for recovery

AR Ansari, H Liu - Archivum Immunologiae et Therapiae Experimentalis, 2017 - Springer
Acute thymic involution (ATI) is usually regarded as a virulence trait. It is caused by several
infectious agents (bacteria, viruses, parasites, fungi) and other factors, including stress …

Tuberculosis, the disrupted immune-endocrine response and the potential thymic repercussion as a contributing factor to disease physiopathology

L D'Attilio, N Santucci, B Bongiovanni… - Frontiers in …, 2018 - frontiersin.org
Upon the pathogen encounter, the host seeks to ensure an adequate inflammatory reaction
to combat infection but at the same time tries to prevent collateral damage, through several …