Antibody-mediated neutralization of SARS-CoV-2

H Gruell, K Vanshylla, T Weber, CO Barnes, C Kreer… - Immunity, 2022 - cell.com
Neutralizing antibodies can block infection, clear pathogens, and are essential to provide
long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies …

[HTML][HTML] COVID-19 antibody tests: a valuable public health tool with limited relevance to individuals

R West, A Kobokovich, N Connell, GK Gronvall - Trends in microbiology, 2021 - cell.com
Antibody tests for detecting past infection with severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) have many uses for public health decision making, but …

[HTML][HTML] Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations

F Muecksch, Y Weisblum, CO Barnes, F Schmidt… - Immunity, 2021 - cell.com
Antibodies elicited by infection accumulate somatic mutations in germinal centers that can
increase affinity for cognate antigens. We analyzed 6 independent groups of clonally related …

[HTML][HTML] Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

Y Weisblum, F Schmidt, F Zhang, J DaSilva, D Poston… - elife, 2020 - elifesciences.org
Neutralizing antibodies elicited by prior infection or vaccination are likely to be key for future
protection of individuals and populations against SARS-CoV-2. Moreover, passively …

[HTML][HTML] Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans

J Seow, C Graham, B Merrick, S Acors, S Pickering… - Nature …, 2020 - nature.com
Antibody responses to SARS-CoV-2 can be detected in most infected individuals 10–15 d
after the onset of COVID-19 symptoms. However, due to the recent emergence of SARS …

Vaccine breakthrough infections with SARS-CoV-2 variants

E Hacisuleyman, C Hale, Y Saito… - … England Journal of …, 2021 - Mass Medical Soc
Emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of
clinical concern. In a cohort of 417 persons who had received the second dose of BNT162b2 …

[HTML][HTML] Maturation and persistence of the anti-SARS-CoV-2 memory B cell response

A Sokal, P Chappert, G Barba-Spaeth, A Roeser… - Cell, 2021 - cell.com
Memory B cells play a fundamental role in host defenses against viruses, but to date, their
role has been relatively unsettled in the context of SARS-CoV-2. We report here a …

Convalescent plasma antibody levels and the risk of death from Covid-19

MJ Joyner, RE Carter, JW Senefeld… - … England Journal of …, 2021 - Mass Medical Soc
Background Convalescent plasma has been widely used to treat coronavirus disease 2019
(Covid-19) under the presumption that such plasma contains potentially therapeutic …

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes

WN Voss, YJ Hou, NV Johnson, G Delidakis, JE Kim… - Science, 2021 - science.org
The molecular composition and binding epitopes of the immunoglobulin G (IgG) antibodies
that circulate in blood plasma after severe acute respiratory syndrome coronavirus 2 (SARS …

Comparative performance of five commercially available serologic assays to detect antibodies to SARS-CoV-2 and identify individuals with high neutralizing titers

EU Patel, EM Bloch, W Clarke, YH Hsieh… - Journal of Clinical …, 2021 - Am Soc Microbiol
Accurate serological assays to detect antibodies to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) are needed to characterize the epidemiology of SARS-CoV-2 …