Transcription factors (TFs) regulate gene programs, thereby controlling diverse cellular
processes and cell states. To comprehensively understand TFs and the programs they …

Transcription factors play an indispensable role in maintaining cellular viability and finely
regulating complex internal metabolic networks. These crucial bioactive functions rely on …

Human pluripotent stem cells (hPSCs) offer an unprecedented opportunity to model diverse
cell types and tissues. To enable systematic exploration of the programming landscape …

The pharmaceutical industry is in high need of efficient and relevant in vitro liver models,
which can be incorporated in their drug discovery pipelines to identify potential drugs and …

The apicomplexan parasite Cryptosporidium is a leading global cause of severe diarrhoeal
disease and an important contributor to early childhood mortality. Currently, there are no …

Zygotic genome activation (ZGA) is an essential transcriptional event in embryonic
development that coincides with extensive epigenetic reprogramming. Complex …

Technologies to reprogram cell-type specification have revolutionized the fields of
regenerative medicine and disease modeling. Currently, the selection of fate-determining …

We propose that the teratoma, a recognized standard for validating pluripotency in stem
cells, could be a promising platform for studying human developmental processes …

TEAD1 and the mammalian Hippo pathway regulate cellular proliferation and function,
though their regulatory function in β cells remains poorly characterized. In this study, we …

Human pluripotent stem cells (hPSCs) are uniquely suited to study human development and
disease and promise to revolutionize regenerative medicine. These applications rely on …