Olfactory immune response to SARS-CoV-2

SA Wellford, EA Moseman - Cellular & Molecular Immunology, 2024 - nature.com
Numerous pathogens can infect the olfactory tract, yet the pandemic caused by SARS-CoV-
2 has strongly emphasized the importance of the olfactory mucosa as an immune barrier …

Age-dependent acquisition of pathogenicity by SARS-CoV-2 Omicron BA. 5

B Imbiakha, S Ezzatpour, DW Buchholz, J Sahler… - Science …, 2023 - science.org
Pathology studies of SARS-CoV-2 Omicron variants of concern (VOC) are challenged by the
lack of pathogenic animal models. While Omicron BA. 1 and BA. 2 replicate in K18-hACE2 …

Endothelial SARS-CoV-2 infection is not the underlying cause of COVID-19-associated vascular pathology in mice

S Gao, AT Tang, M Wang, DW Buchholz… - Frontiers in …, 2023 - frontiersin.org
Endothelial damage and vascular pathology have been recognized as major features of
COVID-19 since the beginning of the pandemic. Two main theories regarding how severe …

[HTML][HTML] Rosmarinic acid alleviates septic acute respiratory distress syndrome in mice by suppressing the bronchial epithelial RAS-mediated ferroptosis

T Zeng, Y Zhou, J Zheng, X Zhuo, L Zhu… - International …, 2024 - Elsevier
Activating angiotensin-converting enzyme 2 (ACE2) is an important player in the
pathogenesis of septic-related acute respiratory distress syndrome (ARDS). Rosmarinic acid …

[HTML][HTML] Rapid Degradation of the Human ACE2 Receptor Upon Binding and Internalization of SARS-Cov-2-Spike-RBD Protein

P Feinstein - bioRxiv, 2024 - ncbi.nlm.nih.gov
It is widely accepted that the SARS-CoV-2 betacoronavirus infects humans through binding
the human Angiotensin Receptor 2 (ACE2) that lines the nasal cavity and lungs, followed by …

Inhibiting Glutamine Metabolism Blocks Coronavirus Replication in Mammalian Cells

KS Greene, A Choi, M Chen, N Yang, R Li, Y Qiu… - bioRxiv, 2023 - biorxiv.org
Developing therapeutic strategies against COVID-19 has gained widespread interest given
the likelihood that new viral variants will continue to emerge. Here we describe one potential …

Immune Barriers in the Olfactory Mucosa

SA Wellford - 2023 - search.proquest.com
The olfactory mucosa is a unique tissue because it directly connects the outside world to the
central nervous system (CNS). From the apical side of the olfactory epithelium, olfactory …