Cellular and molecular mechanisms of Hedgehog signalling
The Hedgehog signalling pathway has crucial roles in embryonic tissue patterning,
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …
International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function
5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …
therapeutics and various drugs in development. Their diversity of structure and function …
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations
P Sakornsakolpat, D Prokopenko, M Lamontagne… - Nature …, 2019 - nature.com
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …
Targeting RAGE signaling in inflammatory disease
BI Hudson, ME Lippman - Annual review of medicine, 2018 - annualreviews.org
The receptor for advanced glycation end-products (RAGE) is a multiligand pattern
recognition receptor implicated in diverse chronic inflammatory states. RAGE binds and …
recognition receptor implicated in diverse chronic inflammatory states. RAGE binds and …
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide.
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
[HTML][HTML] Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in …
Background Understanding the genetic basis of airflow obstruction and smoking behaviour
is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD) …
is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD) …
A large-scale, consortium-based genomewide association study of asthma
MF Moffatt, IG Gut, F Demenais… - … England Journal of …, 2010 - Mass Medical Soc
Background Susceptibility to asthma is influenced by genes and environment; implicated
genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful …
genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful …
Application of high-dimensional feature selection: evaluation for genomic prediction in man
ML Bermingham, R Pong-Wong, A Spiliopoulou… - Scientific reports, 2015 - nature.com
In this study, we investigated the effect of five feature selection approaches on the
performance of a mixed model (G-BLUP) and a Bayesian (Bayes C) prediction method. We …
performance of a mixed model (G-BLUP) and a Bayesian (Bayes C) prediction method. We …