Biocatalytic potential of microorganisms have been employed for centuries to produce
bread, wine, vinegar and other common products without understanding the biochemical …

Controlling the conformation and activity of biomolecules in a reversible manner is a
fascinating challenge (1-3) that has an outstanding potential for the study of and interference …

Bacterial adaptive immunity and genome engineering involving the CRISPR (clustered
regularly interspaced short palindromic repeats)–associated (Cas) protein Cas9 begin with …

Specific interactions between proteins and DNA are fundamental to many biological
processes. In this review, we provide a revised view of protein-DNA interactions that …

Intrinsic disorder refers to segments or to whole proteins that fail to self‐fold into fixed 3D
structure, with such disorder sometimes existing in the native state. Here we report data on …

Posters and lectures presented at the Seventh International Conference on Bioinorganic
Chemistry (ICBIC) in Lubeck, Germany, last year was divided into 16 sections, including …

Fok I is a type IIs restriction endonuclease comprised of a DNA recognition domain and a
catalytic domain. The structural similarity of the Fok I catalytic domain to the type II restriction …

On the basis of a structural analysis of 240 protein-DNA complexes contained in the Protein
Data Bank (PDB), we have classified the DNA-binding proteins involved into eight different …

More than 3000 type II restriction endonucleases have been discovered. They recognize
short, usually palindromic, sequences of 4–8 bp and, in the presence of Mg2+, cleave the …

The long-held views on lock-and-key versus induced fit in binding arose from the notion that
a protein exists in a single, most stable conformation, dictated by its sequence. However, in …