Abstract Macroautophagy (hereafter autophagy), or'self-eating', is a conserved cellular
pathway that controls protein and organelle degradation, and has essential roles in survival …

Autophagy-related (Atg) proteins are eukaryotic factors participating in various stages of the
autophagic process. Thus far 34 Atgs have been identified in yeast, including the key …

Impairment of autophagic degradation of the ubiquitin-and LC3-binding protein" p62" leads
to the formation of cytoplasmic inclusion bodies. However, little is known about the sorting …

Apg8 is a ubiquitin-like protein involved in autophagy in yeast. Apg8 is covalently but
transiently attached to membrane lipids through the actions of activating, conjugating, and …

In yeast, phosphatidylethanolamine is a target of the Atg8 modifier in ubiquitylation-like
reactions essential for autophagy. Three human Atg8 (hAtg8) homologs, LC3, GABARAP …

Abstract γ‐Aminobutyric acid (GABA), an important inhibitory neurotransmitter in both
vertebrates and invertebrates, acts on GABA receptors that are ubiquitously expressed in the …

Microtubule‐associated protein light chain 3 (LC3), a mammalian homologue of yeast Atg8,
plays an essential role in autophagy, which is involved in the bulk degradation of …

GABAA receptors are clustered at synaptic sites to achieve a high density of postsynaptic
receptors opposite the input axonal terminals. This allows for an efficient propagation of …

Autophagy is a bulk degradation pathway that removes cytosolic materials to maintain
cellular homeostasis. The autophagy-related gene 13 (Atg13) and microtubule associate …

Selective autophagy requires the specific segregation of targeted proteins into
autophagosomes. The selectivity is mediated by autophagy receptors, such as p62 and …