The routine and often unavoidable exposure to solar ultraviolet (UV) radiation makes it one
of the most significant environmental DNA-damaging agents to which humans are exposed …

Faithful maintenance of the genome is crucial to the individual and to species. DNA damage
arises from both endogenous sources such as water and oxygen and exogenous sources …

From its very beginning, life has faced the fundamental problem that the form in which
genetic information is stored is not chemically inert. DNA integrity is challenged by the …

Here, we describe the assembly of the nucleotide excision repair (NER) complex in normal
and repair-deficient (xeroderma pigmentosum) human cells, employing a novel technique of …

Eukaryotic cells can repair many types of DNA damage. Among the known DNA repair
processes in humans, one type—nucleotide excision repair (NER)—specifically protects …

Xeroderma pigmentosum (XP) is a rare DNA repair disorder characterized by increased
susceptibility to UV radiation (UVR)-induced skin pigmentation, skin cancers, ocular surface …

Significance: Oxidative DNA damage is repaired by multiple, overlapping DNA repair
pathways. Accumulating evidence supports the hypothesis that nucleotide excision repair …

A versatile strategy for repairing damaged DNA, termed nucleotide excision repair (NER), 1
is found throughout the natural world in organisms ranging from mycoplasma to mammals …

Several types of helix-distorting DNA lesions block the passage of elongating RNA
polymerase II. Surprisingly, such transcription-blocking lesions are usually repaired …

Some details are inevitably lost when attempting to simplify subjects involving complex
medical genetics subjects. However, unless an attempt is made to distill such topics, busy …