Inflammation in Parkinson's disease: mechanisms and therapeutic implications

M Pajares, A I. Rojo, G Manda, L Boscá, A Cuadrado - Cells, 2020 - mdpi.com
Parkinson's disease (PD) is a common neurodegenerative disorder primarily characterized
by the death of dopaminergic neurons that project from the substantia nigra pars compacta …

Current state of Alzheimer's fluid biomarkers

JL Molinuevo, S Ayton, R Batrla, MM Bednar… - Acta …, 2018 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disease with a complex and
heterogeneous pathophysiology. The number of people living with AD is predicted to …

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

AU Joshi, PS Minhas, SA Liddelow… - Nature …, 2019 - nature.com
In neurodegenerative diseases, debris of dead neurons are thought to trigger glia-mediated
neuroinflammation, thus increasing neuronal death. Here we show that the expression of …

The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease

N Lonnemann, S Hosseini… - Proceedings of the …, 2020 - National Acad Sciences
Numerous studies demonstrate that neuroinflammation is a key player in the progression of
Alzheimer's disease (AD). Interleukin (IL)-1β is a main inducer of inflammation and therefore …

Effect of high-fat diets on oxidative stress, cellular inflammatory response and cognitive function

BL Tan, ME Norhaizan - Nutrients, 2019 - mdpi.com
Cognitive dysfunction is linked to chronic low-grade inflammatory stress that contributes to
cell-mediated immunity in creating an oxidative environment. Food is a vitally important …

The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease

A Webers, MT Heneka… - Immunology and cell …, 2020 - Wiley Online Library
Alzheimer's disease (AD) is characterized by amyloid beta (Aβ) accumulation, tau pathology
and neuroinflammation. Recently, there has been considerable interest in the role of …

Modulators of microglial activation and polarization after intracerebral haemorrhage

X Lan, X Han, Q Li, QW Yang, J Wang - Nature Reviews Neurology, 2017 - nature.com
Intracerebral haemorrhage (ICH) is the most lethal subtype of stroke but currently lacks
effective treatment. Microglia are among the first non-neuronal cells on the scene during the …

Microglia in physiology and disease

SA Wolf, H Boddeke… - Annual review of …, 2017 - annualreviews.org
As the immune-competent cells of the brain, microglia play an increasingly important role in
maintaining normal brain function. They invade the brain early in development, transform …

[HTML][HTML] Influence of gut microbiota on neuropsychiatric disorders

MC Cenit, Y Sanz… - World journal of …, 2017 - ncbi.nlm.nih.gov
The last decade has witnessed a growing appreciation of the fundamental role played by an
early assembly of a diverse and balanced gut microbiota and its subsequent maintenance …

Microglia and Alzheimer's disease

S Merighi, M Nigro, A Travagli, S Gessi - International Journal of …, 2022 - mdpi.com
There is a huge need for novel therapeutic and preventative approaches to Alzheimer's
disease (AD) and neuroinflammation seems to be one of the most fascinating solutions. The …