The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment
AP Robinson, CT Harp, A Noronha, SD Miller - Handbook of clinical …, 2014 - Elsevier
While no single model can exactly recapitulate all aspects of multiple sclerosis (MS), animal
models are essential in understanding the induction and pathogenesis of the disease and to …
models are essential in understanding the induction and pathogenesis of the disease and to …
Fundamentals and application of magnetic particles in cell isolation and enrichment: a review
BD Plouffe, SK Murthy, LH Lewis - Reports on Progress in …, 2014 - iopscience.iop.org
Magnetic sorting using magnetic beads has become a routine methodology for the
separation of key cell populations from biological suspensions. Due to the inherent ability of …
separation of key cell populations from biological suspensions. Due to the inherent ability of …
Induced CD4+Foxp3+ Regulatory T Cells in Immune Tolerance
AM Bilate, JJ Lafaille - Annual review of immunology, 2012 - annualreviews.org
Regulatory T lymphocytes are essential to maintain homeostasis of the immune system,
limiting the magnitude of effector responses and allowing the establishment of …
limiting the magnitude of effector responses and allowing the establishment of …
[HTML][HTML] GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice
Tregs not only keep immune responses to autoantigens in check, but also restrain those
directed toward pathogens and the commensal microbiota. Control of peripheral immune …
directed toward pathogens and the commensal microbiota. Control of peripheral immune …
Adoptive immunotherapy for cancer: building on success
L Gattinoni, DJ Powell Jr, SA Rosenberg… - Nature Reviews …, 2006 - nature.com
Adoptive cell transfer after host preconditioning by lymphodepletion represents an important
advance in cancer immunotherapy. Here, we describe how a lymphopaenic environment …
advance in cancer immunotherapy. Here, we describe how a lymphopaenic environment …
Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis
DR Getts, AJ Martin, DP McCarthy, RL Terry… - Nature …, 2012 - nature.com
Aberrant T-cell activation underlies many autoimmune disorders, yet most attempts to induce
T-cell tolerance have failed. Building on previous strategies for tolerance induction that …
T-cell tolerance have failed. Building on previous strategies for tolerance induction that …
Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature
C Kleinschnitz, P Kraft, A Dreykluft… - Blood, The Journal …, 2013 - ashpublications.org
We have recently identified T cells as important mediators of ischemic brain damage, but the
contribution of the different T-cell subsets is unclear. Forkhead box P3 (FoxP3)–positive …
contribution of the different T-cell subsets is unclear. Forkhead box P3 (FoxP3)–positive …
Regulatory T cells in cancer
D Mougiakakos, A Choudhury, A Lladser… - Advances in cancer …, 2010 - Elsevier
At the present time, regulatory T cells (Tregs) are an integral part of immunology but the
route from discovery of “suppressive” lymphocytes in the 1980s to the current established …
route from discovery of “suppressive” lymphocytes in the 1980s to the current established …
A key role of leptin in the control of regulatory T cell proliferation
We report here that leptin can act as a negative signal for the proliferation of human naturally
occurring Foxp3+ CD4+ CD25+ regulatory T (T reg) cells. Freshly isolated T reg cells …
occurring Foxp3+ CD4+ CD25+ regulatory T (T reg) cells. Freshly isolated T reg cells …
CD25: A potential tumor therapeutic target
Y Peng, Y Tao, Y Zhang, J Wang… - … Journal of Cancer, 2023 - Wiley Online Library
CD25 is the alpha‐chain of the heterotrimer IL‐2 receptor. CD25 is expressed on the surface
of both immune and non‐immune cells with different frequencies. For cancers, CD25 is …
of both immune and non‐immune cells with different frequencies. For cancers, CD25 is …