While no single model can exactly recapitulate all aspects of multiple sclerosis (MS), animal
models are essential in understanding the induction and pathogenesis of the disease and to …

Magnetic sorting using magnetic beads has become a routine methodology for the
separation of key cell populations from biological suspensions. Due to the inherent ability of …

Regulatory T lymphocytes are essential to maintain homeostasis of the immune system,
limiting the magnitude of effector responses and allowing the establishment of …

Tregs not only keep immune responses to autoantigens in check, but also restrain those
directed toward pathogens and the commensal microbiota. Control of peripheral immune …

Adoptive cell transfer after host preconditioning by lymphodepletion represents an important
advance in cancer immunotherapy. Here, we describe how a lymphopaenic environment …

Aberrant T-cell activation underlies many autoimmune disorders, yet most attempts to induce
T-cell tolerance have failed. Building on previous strategies for tolerance induction that …

We have recently identified T cells as important mediators of ischemic brain damage, but the
contribution of the different T-cell subsets is unclear. Forkhead box P3 (FoxP3)–positive …

At the present time, regulatory T cells (Tregs) are an integral part of immunology but the
route from discovery of “suppressive” lymphocytes in the 1980s to the current established …

We report here that leptin can act as a negative signal for the proliferation of human naturally
occurring Foxp3+ CD4+ CD25+ regulatory T (T reg) cells. Freshly isolated T reg cells …

CD25 is the alpha‐chain of the heterotrimer IL‐2 receptor. CD25 is expressed on the surface
of both immune and non‐immune cells with different frequencies. For cancers, CD25 is …