Pheochromocytomas and paragangliomas (PCC/PGL) are tumors derived from the adrenal
medulla or extra-adrenal ganglia, respectively. They are rare and often benign tumors that …

Germ line mutations in the VHL tumor-suppressor gene cause von Hippel–Lindau (VHL)
disease, a hereditary neoplastic disease associated with clear-cell renal-cell carcinomas …

The sheer volume of non-synonymous single nucleotide polymorphisms that have been
generated in recent years from projects such as the Human Genome Project, the HapMap …

Succinate dehydrogenase B (SDHB) and D (SDHD) subunit gene mutations predispose to
adrenal and extraadrenal pheochromocytomas, head and neck paragangliomas (HNPGL) …

Mutations in the von Hippel-Lindau (VHL) gene are responsible for VHL disease, congenital
polycythemia, and are found in many sporadic tumor types as well. Reports of VHL …

Next‐generation sequencing methods have not only allowed an understanding of genome
sequence variation during the evolution of organisms but have also provided invaluable …

von Hippel-Lindau (VHL) disease is a rare hereditary cancer syndrome that causes a
predisposition to renal clear-cell carcinoma, hemangioblastoma, pheochromocytoma, and …

Mutations of the von Hippel-Lindau (VHL) gene are frequent in clear cell renal cell
carcinomas (ccRCC). Nonsense and frameshift mutations abrogate the function of the VHL …

Aims Epithelial ovarian cancer (EOC) can be classified into four major types (serous,
endometrioid, clear cell, mucinous). The prevalence of driver gene mutations in the different …

Abstract Drug-resistant tuberculosis (TB), one of the leading causes of death worldwide,
arises mainly from spontaneous mutations in the genome of Mycobacterium tuberculosis …