Classical microtubule‐associated proteins (MAPs) were originally identified based on their
co‐purification with microtubules assembled from mammalian brain lysate. They have since …

Migration of post-mitotic neurons from the ventricular zone to the cortical plate during
embryogenesis comprises one of the most critical stages in brain development. Deficiency of …

Humans with mutations in either DCX or LIS1 display nearly identical neuronal migration
defects, known as lissencephaly. To define subcellular mechanisms, we have combined in …

Neuronal migration is a critical process in the development of the nervous system. Defects in
the migration of the neurons are associated with diseases like lissencephaly, subcortical …

Cerebral cortical development involves a complex series of highly regulated steps to
generate the laminated structure of the adult neocortex. Neuronal migration is a key part of …

Neurons undertake an amazing journey from the center of the developing mammalian brain
to the outer layers of the cerebral cortex. Doublecortin, a component of the microtubule …

We have recently reported a missense mutation in exon 4 of the tubulin alpha 1A (Tuba1a)
gene in a hyperactive N‐ethyl‐N‐nitrosourea (ENU) induced mouse mutant with abnormal …

Advances in genetic tools and sequencing technology in the past few years have vastly
expanded our understanding of the genetics of neurodevelopmental disorders. Recent high …

Mutations in the doublecortin (DCX) gene in human or targeted disruption of the cdk5 gene
in mouse lead to similar cortical lamination defects in the developing brain. Here we show …

The centrosome is an indispensable component of the cell-cycle machinery of eukaryotic
cells, and the perturbation of core centrosomal or centrosome-associated proteins is linked …