Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications

WZ Zhuang, YH Lin, LJ Su, MS Wu, HY Jeng… - Journal of biomedical …, 2021 - Springer
Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy
because of their high immunomodulation ability, tropism towards inflamed and injured …

Advances in mesenchymal stem cell conditioned medium-mediated periodontal tissue regeneration

H Lin, H Chen, X Zhao, Z Chen, P Zhang, Y Tian… - Journal of translational …, 2021 - Springer
Periodontitis is a chronic inflammatory disease that leads to the destruction of both soft and
hard periodontal tissues. Complete periodontal regeneration in clinics using the currently …

Comparative analysis of magnetically activated cell sorting and ultracentrifugation methods for exosome isolation

E Ciftci, N Bozbeyoglu, I Gursel, F Korkusuz… - PloS one, 2023 - journals.plos.org
Mesenchymal stem cell-derived exosomes regulate cell migration, proliferation,
differentiation, and synthesis of the extracellular matrix, giving great potential for the …

The immunomodulatory role of cell-free approaches in SARS-coV-2-induced cytokine storm—A powerful therapeutic tool for COVID-19 patients

M Csobonyeiova, V Smolinska, S Harsanyi… - Biomedicines, 2023 - mdpi.com
Currently, there is still no effective and definitive cure for the coronavirus disease 2019
(COVID-19) caused by the infection of the novel highly contagious severe acute respiratory …

SA/G hydrogel containing hCAP-18/LL-37-engineered WJ-MSCs-derived conditioned medium promoted wound healing in rat model of excision injury

R Sabzevari, AM Roushandeh, A Mehdipour, M Alini… - Life sciences, 2020 - Elsevier
Aim Development and design of efficient wound dressings are subject of intensive
investigations either in basic or in clinical researches. Although, hydrogel-based wound …

Hypoxic extracellular matrix preserves its competence after expansion of human MSCs under physiological hypoxia in vitro

D Matveeva, S Buravkov, E Andreeva, L Buravkova - Biomimetics, 2023 - mdpi.com
Tissue-relevant O2 levels are considered as an important tool for the preconditioning of
multipotent mesenchymal stromal cells (MSCs) for regenerative medicine needs. The …

Therapeutic role of exosomes and conditioned medium in keloid and hypertrophic scar and possible mechanisms

Y Zhong, Y Zhang, A Yu, Z Zhang, Z Deng… - Frontiers in …, 2023 - frontiersin.org
Exosomes, ranging from 40 to 160 nm in diameter, are extracellular lipid bilayer
microvesicles that regulate the body's physiological and pathological processes and are …

The effects of Wharton's jelly MSCs secretomes for restoring busulfan-induced reproductive toxicity in male mice

S Bahmyari, S Alaee, Z Khodabandeh… - Human & …, 2024 - journals.sagepub.com
Several studies investigated the application of Mesenchymal stem cells (MSCs) for treating
spermatogenic disorders. Considering the limitation of MSC application, the present study …

Mesenchymal stem cell-derived exosomes for managing graft-versus-host disease: An updated view

Z Shafeghat, M Dorfaki, S Dehrouyeh, FL Arab… - Transplant …, 2023 - Elsevier
Graft-versus-host disease (GvHD) is the most common complication after stem cell
transplantation, and also it is one of the primary limiting factors for the use of hematopoietic …

Mesenchymal-stem cell-derived conditioned media versus exosomes in the treatment of rat model of polycystic ovary: an attempt to understand the underlying …

SAE Abd-Elwahab, NH Khamis… - Microscopy and …, 2023 - academic.oup.com
Polycystic ovary syndrome (PCOS) is one of the most common endocrine and reproductive
disorders throughout female reproductive age. Cell free therapy [conditioned media (CM) & …