Mesenchymal stem cells for neurological disorders

A Andrzejewska, S Dabrowska, B Lukomska… - Advanced …, 2021 - Wiley Online Library
Neurological disorders are becoming a growing burden as society ages, and there is a
compelling need to address this spiraling problem. Stem cell‐based regenerative medicine …

Mechanism of intranasal drug delivery directly to the brain

TP Crowe, MHW Greenlee, AG Kanthasamy, WH Hsu - Life sciences, 2018 - Elsevier
Neurological diseases are becoming increasingly prominent worldwide due to rapidly aging
populations, which greatly contributes to increasing healthcare costs. The development of …

Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects

M Li, Y Jiang, Q Hou, Y Zhao, L Zhong, X Fu - Stem cell research & …, 2022 - Springer
Mesenchymal stem cell (MSC)-based therapy has been considered as a promising
approach targeting a variety of intractable diseases due to remarkable multiple effect of …

Evaluation of recent intranasal drug delivery systems to the central nervous system

TP Crowe, WH Hsu - Pharmaceutics, 2022 - mdpi.com
Neurological diseases continue to increase in prevalence worldwide. Combined with the
lack of modifiable risk factors or strongly efficacious therapies, these disorders pose a …

Neuroinflammation as a target for treatment of stroke using mesenchymal stem cells and extracellular vesicles

S Dabrowska, A Andrzejewska, B Lukomska… - Journal of …, 2019 - Springer
Ischemic stroke is the third cause of death in the developed countries and the main reason
of severe disability. Brain ischemia leads to the production of damage-associated molecular …

[HTML][HTML] Stem cell therapy for abrogating stroke-induced neuroinflammation and relevant secondary cell death mechanisms

C Stonesifer, S Corey, S Ghanekar, Z Diamandis… - Progress in …, 2017 - Elsevier
Ischemic stroke is a leading cause of death worldwide. A key secondary cell death
mechanism mediating neurological damage following the initial episode of ischemic stroke …

Intranasal treatment of central nervous system dysfunction in humans

CD Chapman, WH Frey, S Craft, L Danielyan… - Pharmaceutical …, 2013 - Springer
One of the most challenging problems facing modern medicine is how to deliver a given
drug to a specific target at the exclusion of other regions. For example, a variety of …

Hypoxia-conditioned mesenchymal stem cells in tissue regeneration application

Y Yang, EH Lee, Z Yang - Tissue Engineering Part B: Reviews, 2022 - liebertpub.com
Mesenchymal stem cells (MSCs) have been demonstrated as promising cell sources for
tissue regeneration due to their capability of self-regeneration, differentiation, and …

Stem cell transplantation therapy for multifaceted therapeutic benefits after stroke

L Wei, ZZ Wei, MQ Jiang, O Mohamad, SP Yu - Progress in neurobiology, 2017 - Elsevier
One of the exciting advances in modern medicine and life science is cell-based
neurovascular regeneration of damaged brain tissues and repair of neuronal structures. The …

Hypoxic preconditioning rejuvenates mesenchymal stem cells and enhances neuroprotection following intracerebral hemorrhage via the miR-326-mediated …

J Liu, J He, L Ge, H Xiao, Y Huang, L Zeng… - Stem cell research & …, 2021 - Springer
Background Intracerebral hemorrhage (ICH) is a major public health concern, and
mesenchymal stem cells (MSCs) hold great potential for treating ICH. However, the quantity …