Targeting nuclear receptors in neurodegeneration and neuroinflammation
S Willems, D Zaienne, D Merk - Journal of medicinal chemistry, 2021 - ACS Publications
Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …
expression upon ligand signals and present as attractive therapeutic targets especially in …
[HTML][HTML] CES2 sustains HNF4α expression to promote pancreatic adenocarcinoma progression through an epoxide hydrolase-dependent regulatory loop
Objective Intra-tumoral expression of the serine hydrolase carboxylesterase 2 (CES2)
contributes to the activation of the pro-drug irinotecan in pancreatic ductal adenocarcinoma …
contributes to the activation of the pro-drug irinotecan in pancreatic ductal adenocarcinoma …
Design of a potent TLX agonist by rational fragment fusion
As a master regulator of neurogenesis, the orphan nuclear receptor tailless homologue
(TLX, NR2E1) maintains neuronal stem cell homeostasis by acting as a transcriptional …
(TLX, NR2E1) maintains neuronal stem cell homeostasis by acting as a transcriptional …
Looking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel
Future lunar missions and beyond will require new and innovative approaches to radiation
countermeasures. The Translational Research Institute for Space Health (TRISH) is focused …
countermeasures. The Translational Research Institute for Space Health (TRISH) is focused …
Glial PAMPering and DAMPening of Adult Hippocampal Neurogenesis
L Parkitny, M Maletic-Savatic - Brain Sciences, 2021 - mdpi.com
Adult neurogenesis represents a mature brain's capacity to integrate newly generated
neurons into functional circuits. Impairment of neurogenesis contributes to the …
neurons into functional circuits. Impairment of neurogenesis contributes to the …
Bioinformatics exploration of olive oil: molecular targets and properties of major bioactive constituents
TH Fatoki, CO Akintayo, O Ibraheem - OCL, 2021 - ocl-journal.org
Olive oil possesses medicinal properties which include antimicrobial, antioxidant and anti-
inflammatory, anti-diabetes, and anti-cardiovascular diseases. Oleic acid is the most …
inflammatory, anti-diabetes, and anti-cardiovascular diseases. Oleic acid is the most …
[HTML][HTML] Retinal Degeneration: Short-Term Options and Long-Term Vision for Future Therapy
S Majidi, JM Ogilvie, CA Flaveny - Missouri Medicine, 2021 - ncbi.nlm.nih.gov
The leading cause blindness is the loss of retinal ganglion cells which connect the retina to
the brain. Degenerative retinal diseases include retinal dystrophy, macular degeneration …
the brain. Degenerative retinal diseases include retinal dystrophy, macular degeneration …