A novel human cellular model of CDA IV enables comprehensive analysis revealing the molecular basis of the disease phenotype

I Ferrer-Vicens, DCJ Ferguson… - Blood, The Journal …, 2023 - ashpublications.org
Red blood cell disorders can result in severe anemia. One such disease congenital
dyserythropoietic anemia IV (CDA IV) is caused by the heterozygous mutation E325K in the …

Erythroid Krüppel-Like Factor (KLF1): A Surprisingly Versatile Regulator of Erythroid Differentiation

JJ Bieker, S Philipsen - Transcription factors in blood cell development, 2024 - Springer
Erythroid Krüppel-like factor (KLF1), first discovered in 1992, is an erythroid-restricted
transcription factor (TF) that is essential for terminal differentiation of erythroid progenitors. At …

Identification and characterization of RBM12 as a novel regulator of fetal hemoglobin expression

A Wakabayashi, M Kihiu, M Sharma… - Blood …, 2022 - ashpublications.org
The fetal-to-adult hemoglobin transition is clinically relevant because reactivation of fetal
hemoglobin (HbF) significantly reduces morbidity and mortality associated with sickle cell …

Elevating fetal hemoglobin–recently discovered regulators and mechanisms

E Khandros, GA Blobel - Blood, 2024 - Elsevier
It has been known for over half a century that humans produce different forms of
hemoglobin, a tetramer of α-and β-like hemoglobin chains, throughout ontogeny. The switch …

Pumilio RNA binding family member 1 deficiency activates anti-tumor immunity in hepatocellular carcinoma via restraining M2 macrophage polarization

Y Yu, G Nie, YW Ren, L Ouyang, CM Ni - Cell Cycle, 2024 - Taylor & Francis
Pumilio RNA-binding family member 1 (PUM1) has been implicated in both the progression
of colorectal cancer and the regulation of inflammation. The role of PUM1 in the polarization …