Abstract CD95 (APO-1/Fas) is a prototype death receptor characterized by the presence of
an 80 amino acid death domain in its cytoplasmic tail. This domain is essential for the …

During the course of an immune response, antigen-reactive T cells clonally expand and then
are removed by apoptosis to maintain immune homeostasis. Life and death of T cells is …

Upon stimulation, CD95 (APO-1/Fas) recruits the adapter molecule FADD/MORT1,
procaspase-8, and the cellular FLICE-inhibitory proteins (c-FLIP) into the death-inducing …

Cell death is executed along several pathways. Apart from necrotic cell death occurring
upon tissue injury, several distinct types of apoptosis have been observed. Apoptosis, or …

Several proteins can traverse biological membranes through protein transduction. Small
sections of these proteins (10–16 residues long) are responsible for this. Linking these …

In recent years, vast amounts of data on the mechanisms of neural de-and regeneration
have accumulated. However, only in disproportionally few cases has this led to efficient …

Abstract Heat shock protein 27 (HSP27) confers cellular protection against a variety of
cytotoxic stresses and also against physiological stresses associated with growth arrest or …

TRAIL (TNF-related apoptosis-inducing ligand) is a member of the TNF family that induces
apoptosis in a variety of cancer cells. In this study, we demonstrate that human CD11c+ …

Abstract Resveratrol (trans-3, 4′, 5,-trihydroxystilbene), a phytoalexin found in grapes, nuts,
fruits, and red wine, is a potent antioxidant with cancer-preventive properties. The …

Lymphocyte homeostasis is a balance between lymphocyte proliferation and lymphocyte
death. Tight control of apoptosis is essential for immune function, because its altered …