[HTML][HTML] Tumor-on-a-chip: from bioinspired design to biomedical application

X Liu, J Fang, S Huang, X Wu, X Xie, J Wang… - Microsystems & …, 2021 - nature.com
Cancer is one of the leading causes of human death, despite enormous efforts to explore
cancer biology and develop anticancer therapies. The main challenges in cancer research …

Gut microbiota and their metabolites in stroke: a double-edged sword

A Peh, JA O'Donnell, BRS Broughton, FZ Marques - Stroke, 2022 - Am Heart Assoc
Besides damaging the brain, stroke causes systemic changes, including to the
gastrointestinal system. A growing body of evidence supports the role of the gut and its …

[HTML][HTML] Mouse microbiota models: comparing germ-free mice and antibiotics treatment as tools for modifying gut bacteria

EA Kennedy, KY King, MT Baldridge - Frontiers in physiology, 2018 - frontiersin.org
As the intestinal microbiota has become better appreciated as necessary for maintenance of
physiologic homeostasis and also as a modulator of disease processes, there has been a …

Microbial ecology along the gastrointestinal tract

ET Hillman, H Lu, T Yao, CH Nakatsu - Microbes and environments, 2017 - jstage.jst.go.jp
The ecosystem of the human gastrointestinal (GI) tract traverses a number of environmental,
chemical, and physical conditions because it runs from the oral cavity to the anus. These …

Transplantation of microbiota from drug-free patients with schizophrenia causes schizophrenia-like abnormal behaviors and dysregulated kynurenine metabolism in …

F Zhu, R Guo, W Wang, Y Ju, Q Wang, Q Ma… - Molecular …, 2020 - nature.com
Accumulating evidence suggests that gut microbiota plays a role in the pathogenesis of
schizophrenia via the microbiota–gut–brain axis. This study sought to investigate whether …

[HTML][HTML] Exploring the emerging role of the microbiome in cancer immunotherapy

J Fessler, V Matson, TF Gajewski - Journal for immunotherapy of cancer, 2019 - Springer
The activity of the commensal microbiota significantly impacts human health and has been
linked to the development of many diseases, including cancer. Gnotobiotic animal models …

Growing up in a bubble: using germ-free animals to assess the influence of the gut microbiota on brain and behavior

P Luczynski, KA McVey Neufeld… - International Journal …, 2016 - academic.oup.com
There is a growing recognition of the importance of the commensal intestinal microbiota in
the development and later function of the central nervous system. Research using germ-free …

[HTML][HTML] Multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines

C Li, W Jia, J Yang, C Cheng, OE Olaleye - Acta Pharmacologica Sinica, 2022 - nature.com
Traditional medicine has provided a basis for health care and disease treatment to Chinese
people for millennia, and herbal medicines are regulated as drug products in China …

Synthetic microbial communities (SynComs) of the human gut: design, assembly, and applications

PT van Leeuwen, S Brul, J Zhang… - FEMS microbiology …, 2023 - academic.oup.com
The human gut harbors native microbial communities, forming a highly complex ecosystem.
Synthetic microbial communities (SynComs) of the human gut are an assembly of …

Dendrobium officinale Polysaccharide Alleviates Type 2 Diabetes Mellitus by Restoring Gut Microbiota and Repairing Intestinal Barrier via the LPS/TLR4/TRIF/NF-kB …

X Chen, C Chen, X Fu - Journal of Agricultural and Food …, 2023 - ACS Publications
Dendrobium officinale polysaccharide (DOP), the main active component, has a variety of
bioactivities. In this study, a type 2 diabetes mellitus (T2DM) and antibiotic-induced pseudo …