Drug resistance in influenza A virus: the epidemiology and management

M Hussain, HD Galvin, TY Haw… - Infection and drug …, 2017 - Taylor & Francis
Influenza A virus (IAV) is the sole cause of the unpredictable influenza pandemics and
deadly zoonotic outbreaks and constitutes at least half of the cause of regular annual …

Zoonotic potential of influenza A viruses: a comprehensive overview

A Mostafa, EM Abdelwhab, TC Mettenleiter, S Pleschka - Viruses, 2018 - mdpi.com
Influenza A viruses (IAVs) possess a great zoonotic potential as they are able to infect
different avian and mammalian animal hosts, from which they can be transmitted to humans …

Theoretical basis of the test-negative study design for assessment of influenza vaccine effectiveness

SG Sullivan, EJ Tchetgen Tchetgen… - American journal of …, 2016 - academic.oup.com
Influenza viruses undergo frequent antigenic changes. As a result, the viruses circulating
change within and between seasons, and the composition of the influenza vaccine is …

Antithrombotic therapy in patients with COVID-19?-Rationale and Evidence

C Godino, A Scotti, N Maugeri, N Mancini… - International journal of …, 2021 - Elsevier
In patients with severe or critical Coronavirus disease 2019 (COVID-19) manifestations, a
thromboinflammatory syndrome, with diffuse microvascular thrombosis, is increasingly …

Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms

D Hughes, DI Andersson - Nature Reviews Genetics, 2015 - nature.com
Drug therapy has a crucial role in the treatment of viral, bacterial, fungal and protozoan
infections, as well as the control of human cancer. The success of therapy is being …

Clinical implications of antiviral resistance in influenza

TCM Li, MCW Chan, N Lee - Viruses, 2015 - mdpi.com
Influenza is a major cause of severe respiratory infections leading to excessive
hospitalizations and deaths globally; annual epidemics, pandemics, and sporadic/endemic …

The epidemiology and spread of drug resistant human influenza viruses

AC Hurt - Current opinion in virology, 2014 - Elsevier
Highlights•Changes in the circulation of antiviral-resistant influenza viruses have
occurred.•All human influenza viruses are currently resistant to the adamantanes.•Little …

Platelet activation and aggregation promote lung inflammation and influenza virus pathogenesis

VB Lê, JG Schneider, Y Boergeling, F Berri… - American journal of …, 2015 - atsjournals.org
Rationale: The hallmark of severe influenza virus infection is excessive inflammation of the
lungs. Platelets are activated during influenza, but their role in influenza virus pathogenesis …

Neuraminidase inhibitor resistance in influenza: a clinical perspective

N Lee, AC Hurt - Current opinion in infectious diseases, 2018 - journals.lww.com
These findings highlight the importance of continuous surveillance, and assessment of viral
fitness and transmissibility of resistant virus strains. Detection can be challenging, especially …

[HTML][HTML] Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2013–2014

E Takashita, A Meijer, A Lackenby, L Gubareva… - Antiviral research, 2015 - Elsevier
Abstract Four World Health Organization (WHO) Collaborating Centres for Reference and
Research on Influenza and one WHO Collaborating Centre for the Surveillance …