The fibroblast growth factor (Fgf) family of ligands and receptor tyrosine kinases is required
throughout embryonic and postnatal development and also regulates multiple homeostatic …

This review covers recent advances in understanding the molecular mechanisms controlling
neurogenesis and specification of the developing retina, with a focus on insights obtained …

Human eye development is coordinated through an extensive network of genetic signalling
pathways. Disruption of key regulatory genes in the early stages of eye development can …

Dysfunction and loss of the retinal pigment epithelium (RPE) are hallmarks of retinal
degenerative diseases in mammals. A critical transcription factor for RPE development and …

Precise regulation of the amplitude and duration of receptor tyrosine kinase (RTK) signaling
is critical for the execution of cellular programs and behaviors. Understanding these control …

Astrocytes represent the earliest glial population in the embryonic optic nerve, contributing
critically to retinal angiogenesis and formation of brain‐retinal‐barrier. Despite of many …

Embryonic development of the vertebrate eye begins with the formation of an optic vesicle
which folds inwards to form a double-layered optic cup with a fissure on the ventral surface …

Ocular coloboma is an uncommon, but often severe, sight-threatening condition that can be
identified from birth. This congenital anomaly is thought to be caused by maldevelopment of …

The vertebrate eye is derived from the neuroepithelium, surface ectoderm, and extracellular
mesenchyme. The neuroepithelium forms an optic cup in which the spatial separation of …

The developing vertebrate eye cup is partitioned into the neural retina (NR), the retinal
pigmented epithelium (RPE), and the ciliary margin (CM). By single-cell analysis, we …