Liver transplantation (LT) was historically associated with massive blood loss and
transfusion. Over the past two decades transfusion requirements have reduced dramatically …

Trauma remains the leading cause of death, with bleeding as the primary cause of
preventable mortality. When death occurs, it happens quickly, typically within the first 6 h …

Objectives Sustained changes in resuscitation and transfusion management have been
observed since the turn of the millennium, along with an ongoing discussion of surgical …

BACKGROUND Massive transfusion (MT) in pediatric patients remains poorly defined.
Using the largest existing registry of transfused pediatric trauma patients, we sought a data …

Apixaban is a new oral anticoagulant with a specific inhibitory action on FXa. No information
is available on the reversal of the antihemostatic action of apixaban in experimental or …

Objective To ascertain the incidence of massive transfusion (MT) in obstetrics in the UK, and
describe its management and clinical outcomes. Design A population‐based cross …

Background: Hemorrhage coupled with coagulopathy remains the leading cause of
preventable in-hospital deaths among trauma patients. Use of a transfusion protocol with a …

OBJECTIVES Prothrombin complex concentrates (PCCs) are sometimes used as 'off
label'for excessive bleeding after cardiopulmonary bypass (CPB). The main objective of this …

Massive haemorrhage is common and often associated with high morbidity and mortality.
We perform a systematic review of the literature, with extraction of the recommendations …

BACKGROUND The classic definition of massive transfusion, 10 or more units of red blood
cells (RBCs) in 24 hours, has never been demonstrated as a valid surrogate for severe …