Objective: Next-generation sequencing data has been widely used for DNA variant
discovery and tumor study through computational tools. Effective simulation of such data …

Sequence alignment is just as much a part of phylogenetics as is tree building, although it is
often viewed solely as a necessary tool to construct trees. However, alignment for the …

Intrinsically disordered protein regions are abundant in eukaryotic proteins and lack stable
tertiary structures and enzymatic functions. Previous studies of disordered region evolution …

A fundamental goal in evolutionary biology and population genetics is to understand how
selection shapes the fate of new mutations. Here, we test the null hypothesis that insertion …

Abstract In South America, Lutzomyia umbratilis is the main vector of Leishmania
guyanensis, one of the species involved in the transmission of American tegumentary …

Ancestral allele information is useful for genetics studies. Previously, the identification of
ancestral alleles was primarily based on sequence alignments between species. Alternative …

Segmental duplications are an important class of mutations. Because a large proportion of
segmental duplications may often be strongly deleterious, high frequency or fixed segmental …

Na América do Sul, Lutzomyia umbratilis é o principal vetor de Leishmania guyanensis, uma
das espécies envolvidas na transmissão da leishmaniose tegumentar americana. No Brasil …