European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender
TT Seppälä, A Latchford, I Negoi… - British Journal of …, 2021 - academic.oup.com
Background Lynch syndrome is the most common genetic predisposition for hereditary
cancer but remains underdiagnosed. Large prospective observational studies have recently …
cancer but remains underdiagnosed. Large prospective observational studies have recently …
ACG clinical guideline: genetic testing and management of hereditary gastrointestinal cancer syndromes
S Syngal, RE Brand, JM Church… - Official journal of the …, 2015 - journals.lww.com
This guideline presents recommendations for the management of patients with hereditary
gastrointestinal cancer syndromes. The initial assessment is the collection of a family history …
gastrointestinal cancer syndromes. The initial assessment is the collection of a family history …
Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and …
KJ Monahan, N Bradshaw, S Dolwani, B Desouza… - Gut, 2020 - gut.bmj.com
Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost
30% of the population in the UK have a family history of CRC. The quantification of an …
30% of the population in the UK have a family history of CRC. The quantification of an …
Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts
Lynch syndrome (LS) is characterised by the development of colorectal cancer, endometrial
cancer and various other cancers, and is caused by a mutation in one of the mismatch repair …
cancer and various other cancers, and is caused by a mutation in one of the mismatch repair …
Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome
V Bonadona, B Bonaïti, S Olschwang, S Grandjouan… - Jama, 2011 - jamanetwork.com
Context Providing accurate estimates of cancer risks is a major challenge in the clinical
management of Lynch syndrome. Objective To estimate the age-specific cumulative risks of …
management of Lynch syndrome. Objective To estimate the age-specific cumulative risks of …
Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002)
SR Cairns, JH Scholefield, RJ Steele, MG Dunlop… - Gut, 2010 - gut.bmj.com
The British Society of Gastroenterology (BSG) and the Association of Coloproctology for
Great Britain and Ireland (ACPGBI) commissioned this update of the 2002 guidance. The …
Great Britain and Ireland (ACPGBI) commissioned this update of the 2002 guidance. The …
Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on colorectal cancer
FM Giardiello, JI Allen, JE Axilbund, CR Boland… - Gastroenterology, 2014 - Elsevier
The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to
assist health care providers with the appropriate provision of genetic testing and …
assist health care providers with the appropriate provision of genetic testing and …
Endometrial cancer in Lynch syndrome
S Zhao, L Chen, Y Zang, W Liu, S Liu… - … Journal of Cancer, 2022 - Wiley Online Library
Lynch syndrome (LS) is an autosomal dominant inherited disease caused by germline
pathogenic variants (PVs) in mismatch repair (MMR) genes. LS‐associated endometrial …
pathogenic variants (PVs) in mismatch repair (MMR) genes. LS‐associated endometrial …
The immune biology of microsatellite-unstable cancer
M Kloor, M von Knebel Doeberitz - Trends in cancer, 2016 - cell.com
Deficient DNA mismatch repair (MMR) boosts the accumulation of frameshift mutations in
genes encompassing coding microsatellites (cMS). This results in the translation of proteins …
genes encompassing coding microsatellites (cMS). This results in the translation of proteins …
Risk of pancreatic cancer in families with Lynch syndrome
Context Lynch syndrome is an inherited cause of colorectal cancer caused by mutations of
DNA mismatch repair (MMR) genes. A number of extracolonic tumors have been associated …
DNA mismatch repair (MMR) genes. A number of extracolonic tumors have been associated …