Background Lynch syndrome is the most common genetic predisposition for hereditary
cancer but remains underdiagnosed. Large prospective observational studies have recently …

This guideline presents recommendations for the management of patients with hereditary
gastrointestinal cancer syndromes. The initial assessment is the collection of a family history …

Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost
30% of the population in the UK have a family history of CRC. The quantification of an …

Lynch syndrome (LS) is characterised by the development of colorectal cancer, endometrial
cancer and various other cancers, and is caused by a mutation in one of the mismatch repair …

Context Providing accurate estimates of cancer risks is a major challenge in the clinical
management of Lynch syndrome. Objective To estimate the age-specific cumulative risks of …

The British Society of Gastroenterology (BSG) and the Association of Coloproctology for
Great Britain and Ireland (ACPGBI) commissioned this update of the 2002 guidance. The …

The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to
assist health care providers with the appropriate provision of genetic testing and …

Lynch syndrome (LS) is an autosomal dominant inherited disease caused by germline
pathogenic variants (PVs) in mismatch repair (MMR) genes. LS‐associated endometrial …

Deficient DNA mismatch repair (MMR) boosts the accumulation of frameshift mutations in
genes encompassing coding microsatellites (cMS). This results in the translation of proteins …

Context Lynch syndrome is an inherited cause of colorectal cancer caused by mutations of
DNA mismatch repair (MMR) genes. A number of extracolonic tumors have been associated …