Arylamine N‐acetyltransferases (NAT s) are polymorphic drug‐metabolizing enzymes,
acetylating arylamine carcinogens and drugs including hydralazine and sulphonamides …

Mycolic acids are the major lipid components of the unique mycobacterial cell wall
responsible for the protection of the tuberculosis bacilli from many outside threats. Mycolic …

Mycobacterium tuberculosis is able to use a variety of carbon sources in vivo and current
knowledge suggests that cholesterol is used as a carbon source during infection. The …

ATP-dependent Mur ligases (Mur synthetases) play essential roles in the biosynthesis of cell
wall peptidoglycan (PG) as they catalyze the ligation of key amino acid residues to the stem …

In the recently identified cholesterol catabolic pathway of Mycobacterium tuberculosis, 2-
hydroxy-6-oxo-6-phenylhexa-2, 4-dienoate hydrolase (HsaD) is proposed to catalyze the …

Arylamine N-acetyltransferases (NATs) are defined as xenobiotic metabolizing enzymes,
adding an acetyl group from acetyl coenzyme A (CoA) to arylamines and arylhydrazines …

New anti-tubercular drugs and drug targets are urgently needed to reduce the time for
treatment and also to identify agents that will be effective against Mycobacterium …

Microbial NAT enzymes, which employ acyl-CoA to acylate aromatic amines and
hydrazines, have been well-studied for their role in xenobiotic metabolism. Some …

A hallmark of Mycobacterium tuberculosis (M. tb), the aetiologic agent of tuberculosis, is its
ability to metabolise host‐derived lipids. However, the enzymes and mechanisms underlying …

Arylamine N-acetyltransferase from Mycobacterium tuberculosis (TBNAT) plays an important
role in the intracellular survival of the microorganism inside macrophages. Medicinal …