Abstract Narcolepsy type 1 (NT1) is a chronic sleep disorder resulting from the loss of a
small population of hypothalamic neurons that produce wake-promoting hypocretin (HCRT; …

The orexin/hypocretin neuropeptide family has emerged as a focal point of neuroscientific
research following the discovery that this family plays a crucial role in a variety of …

Cancer is the second major cause of disease-related death worldwide, and its accurate
early diagnosis and therapeutic intervention are fundamental for saving the patient's life …

Narcolepsy is a chronic sleep disorder that disrupts the regulation of a person's sleep–wake
cycle, leading to significant challenges in daily functioning. It is characterized by excessive …

Abstract Background Narcolepsy type 1 (NT1) is a chronic disorder characterized by
pathological daytime sleepiness and cataplexy due to the disappearance of orexin …

Abstract Study Objectives Narcolepsy type 1 (NT1) is a neurological sleep disorder.
Postmortem studies have shown 75%–90% loss of the 50 000–70 000 hypocretin-producing …

The orexin system consists of the peptide transmitters orexin-A and-B and the G protein-
coupled orexin receptors OX1 and OX2. Orexin receptors are capable of coupling to all four …

Objective Narcolepsy type 1 is a primary sleep disorder caused by deficient hypocretin
transmission leading to excessive daytime sleepiness and cataplexy. Opioids have been …

The postpartum period is a demanding time during which mothers experience numerous
physiological adaptations that enable them to care for their offspring while maintaining their …

Abstract Narcolepsy type 1 (NT1), characterized by the loss of hypocretin/orexin (HCRT)
production in the lateral hypothalamus, has been linked to Pandemrix vaccination during the …