The immunopathogenesis of narcolepsy type 1
Abstract Narcolepsy type 1 (NT1) is a chronic sleep disorder resulting from the loss of a
small population of hypothalamic neurons that produce wake-promoting hypocretin (HCRT; …
small population of hypothalamic neurons that produce wake-promoting hypocretin (HCRT; …
The Orexin/Hypocretin System, the Peptidergic Regulator of Vigilance, Orchestrates Adaptation to Stress
The orexin/hypocretin neuropeptide family has emerged as a focal point of neuroscientific
research following the discovery that this family plays a crucial role in a variety of …
research following the discovery that this family plays a crucial role in a variety of …
Systems Biology in Cancer Diagnosis Integrating Omics Technologies and Artificial Intelligence to Support Physician Decision Making
A Fawaz, A Ferraresi, C Isidoro - Journal of Personalized Medicine, 2023 - mdpi.com
Cancer is the second major cause of disease-related death worldwide, and its accurate
early diagnosis and therapeutic intervention are fundamental for saving the patient's life …
early diagnosis and therapeutic intervention are fundamental for saving the patient's life …
Exploring the literature on narcolepsy: insights into the sleep disorder that strikes during the day
AM Mațotă, A Bordeianu, E Severin, A Jidovu - NeuroSci, 2023 - mdpi.com
Narcolepsy is a chronic sleep disorder that disrupts the regulation of a person's sleep–wake
cycle, leading to significant challenges in daily functioning. It is characterized by excessive …
cycle, leading to significant challenges in daily functioning. It is characterized by excessive …
Connecting the dots: An updated review of the role of autoimmunity in narcolepsy and emerging immunotherapeutic approaches
Abstract Background Narcolepsy type 1 (NT1) is a chronic disorder characterized by
pathological daytime sleepiness and cataplexy due to the disappearance of orexin …
pathological daytime sleepiness and cataplexy due to the disappearance of orexin …
Larger hypothalamic volume in narcolepsy type 1
Abstract Study Objectives Narcolepsy type 1 (NT1) is a neurological sleep disorder.
Postmortem studies have shown 75%–90% loss of the 50 000–70 000 hypocretin-producing …
Postmortem studies have shown 75%–90% loss of the 50 000–70 000 hypocretin-producing …
International Union of Basic and Clinical Pharmacology CXIV: Orexin Receptor Function, Nomenclature and Pharmacology
JP Kukkonen, LH Jacobson… - Pharmacological …, 2024 - pharmrev.aspetjournals.org
The orexin system consists of the peptide transmitters orexin-A and-B and the G protein-
coupled orexin receptors OX1 and OX2. Orexin receptors are capable of coupling to all four …
coupled orexin receptors OX1 and OX2. Orexin receptors are capable of coupling to all four …
[HTML][HTML] The therapeutic potential of opioids in narcolepsy type 1: a systematic literature review and questionnaire study
JK Gool, EM van Heese, MS Schinkelshoek… - Sleep Medicine, 2023 - Elsevier
Objective Narcolepsy type 1 is a primary sleep disorder caused by deficient hypocretin
transmission leading to excessive daytime sleepiness and cataplexy. Opioids have been …
transmission leading to excessive daytime sleepiness and cataplexy. Opioids have been …
Hypocretins, sleep, and maternal behavior
M Rivas, A Ferreira, P Torterolo… - Frontiers in behavioral …, 2023 - frontiersin.org
The postpartum period is a demanding time during which mothers experience numerous
physiological adaptations that enable them to care for their offspring while maintaining their …
physiological adaptations that enable them to care for their offspring while maintaining their …
Downregulation of hypocretin/orexin after H1N1 Pandemrix vaccination of adolescent mice
N Pagh-Berendtsen, A Pavlovskyi, D Flores Téllez… - Sleep, 2024 - academic.oup.com
Abstract Narcolepsy type 1 (NT1), characterized by the loss of hypocretin/orexin (HCRT)
production in the lateral hypothalamus, has been linked to Pandemrix vaccination during the …
production in the lateral hypothalamus, has been linked to Pandemrix vaccination during the …