The impact of HIV-1 within-host evolution on transmission dynamics

K Theys, P Libin, AC Pineda-Pena, A Nowe… - Current opinion in …, 2018 - Elsevier
Highlights•HIV-1 within-host evolution is short-sighted and favours more virulent
viruses.•Systemic HIV-1 infection is mainly established by a single variant …

Quasispecies of SARS-CoV-2 revealed by single nucleotide polymorphisms (SNPs) analysis

R Gao, W Zu, Y Liu, J Li, Z Li, Y Wen, H Wang, J Yuan… - Virulence, 2021 - Taylor & Francis
New SARS-CoV-2 mutants have been continuously indentified with enhanced transmission
ever since its outbreak in early 2020. As an RNA virus, SARS-CoV-2 has a high mutation …

New SHIVs and improved design strategy for modeling HIV-1 transmission, immunopathogenesis, prevention, and cure

H Li, S Wang, FH Lee, RS Roark, AI Murphy… - Journal of …, 2021 - Am Soc Microbiol
Previously, we showed that substitution of HIV-1 envelope (Env) residue 375-Ser by bulky
aromatic residues enhances binding to rhesus CD4 and enables primary HIV-1 Envs to …

[HTML][HTML] B cell engagement with HIV-1 founder virus envelope predicts development of broadly neutralizing antibodies

SM Townsley, GC Donofrio, N Jian, DJ Leggat… - Cell host & …, 2021 - cell.com
Determining which immunological mechanisms contribute to the development of broad
neutralizing antibodies (bNAbs) during HIV-1 infection is a major goal to inform vaccine …

The HIV-1 Env gp120 inner domain shapes the Phe43 cavity and the CD4 binding site

J Prévost, WD Tolbert, H Medjahed, RT Sherburn… - MBio, 2020 - Am Soc Microbiol
The HIV-1 envelope glycoproteins (Env) undergo conformational changes upon interaction
of the gp120 exterior glycoprotein with the CD4 receptor. The gp120 inner domain …

Inferring the multiplicity of founder variants initiating HIV-1 infection: a systematic review and individual patient data meta-analysis

J Baxter, S Langhorne, T Shi, DC Tully… - The Lancet …, 2023 - thelancet.com
Background HIV-1 infections initiated by multiple founder variants are characterised by a
higher viral load and a worse clinical prognosis than those initiated with single founder …

[HTML][HTML] Terminal effector CD8 T cells defined by an IKZF2+ IL-7R− transcriptional signature express FcγRIIIA, expand in HIV infection, and mediate potent HIV-specific …

P Naluyima, KG Lal, MC Costanzo… - The Journal of …, 2019 - journals.aai.org
HIV-1 infection expands large populations of late-stage differentiated CD8 T cells that may
persist long after viral escape from TCR recognition. In this study, we investigated whether …

Evolution of antibody responses in HIV-1 CRF01_AE acute infection: founder envelope V1V2 impacts the timing and magnitude of autologous neutralizing antibodies

S Kuriakose Gift, L Wieczorek, E Sanders-Buell… - Journal of …, 2023 - Am Soc Microbiol
Understanding the dynamics of early immune responses to HIV-1 infection, including the
evolution of initial neutralizing and antibody-dependent cellular cytotoxicity (ADCC) …

Evolution of HIV-1 within untreated individuals and at the population scale in Uganda

J Raghwani, AD Redd, AF Longosz, CH Wu… - PLoS …, 2018 - journals.plos.org
HIV-1 undergoes multiple rounds of error-prone replication between transmission events,
resulting in diverse viral populations within and among individuals. In addition, the virus …

HIV-1 diversity in viral reservoirs obtained from circulating T-cell subsets during early ART and beyond

Y Zhang, F Otte, M Stoeckle, A Thielen… - PLoS …, 2024 - journals.plos.org
Even during extended periods of effective immunological control, a substantial dynamic of
the viral genome can be observed in different cellular compartments in HIV-1 positive …