Methotrexate (MTX) is one of the most effective and widely used drugs in the management of
autoimmune and dermatological diseases. Rheumatoid arthritis and psoriasis patients who …

Background: Natural product-based cancer preventive and therapeutic entities, such as
flavonoids and their derivatives, are shown to have a noticeable capability to suppress tumor …

Highlights•Naringin induced a marked decrease of renal injury markers in MTX-treated
rats.•Naringin protected against redox imbalance of renal tissue in MTX-treated …

Background Liver is a vital organ responsible for metabolizing and detoxifying both
endogenous and exogenous substances in the body. However, it is susceptible to damage …

Methotrexate is a key component of the treatment of inflammatory rheumatic diseases and
the mainstay of therapy in rheumatoid arthritis. Hepatotoxicity has long been a concern for …

Citrus fruits are grown worldwide for their special nutritive and several health benefits.
Among citrus bioactives, naringenin, a major flavanone, exhibits a potential hepatoprotective …

Methotrexate (MTX) is used as an effective chemotherapeutic agent against autoimmune
diseases and tumors. Oxidative stress and inflammation are involved in the pathogenesis of …

This study aims to investigate the wound-healing effectiveness of the phenolic compound,
naringin, both in vitro and in vivo. Male mice were shaved on their dorsal skin under …

Inflammation accompanies hepatic dysfunction resulting from tissue oxidative damage.
Naringenin (Nar), a natural flavanone, has known antioxidant and anti-inflammatory …

A dual-drug delivery system (DDDS) based on oxidized alginate (OxAlg) and carboxymethyl
chitosan (CMCS) is developed, which can be used for dual-responsive delivery of …