Store-operated calcium channels: from function to structure and back again

RS Lewis - Cold Spring Harbor perspectives in biology, 2020 - cshperspectives.cshlp.org
Store-operated calcium (Ca2+) entry (SOCE) occurs through a widely distributed family of
ion channels activated by the loss of Ca2+ from the endoplasmic reticulum (ER). The best …

[HTML][HTML] STIM1 activation of Orai1

V Lunz, C Romanin, I Frischauf - Cell calcium, 2019 - Elsevier
Abstract A primary calcium (Ca 2+) entry pathway into non-excitable cells is through the
store-operated Ca 2+ release activated Ca 2+(CRAC) channel. Ca 2+ entry into cells is …

Molecular mechanisms of STIM/Orai communication

I Derler, I Jardin, C Romanin - American Journal of …, 2016 - journals.physiology.org
Ca2+ entry into the cell via store-operated Ca2+ release-activated Ca2+ (CRAC) channels
triggers diverse signaling cascades that affect cellular processes like cell growth, gene …

Calcium ions in aqueous solutions: Accurate force field description aided by ab initio molecular dynamics and neutron scattering

T Martinek, E Duboué-Dijon, Š Timr… - The Journal of …, 2018 - pubs.aip.org
We present a combination of force field and ab initio molecular dynamics simulations
together with neutron scattering experiments with isotopic substitution that aim at …

Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation

X Hou, IR Outhwaite, L Pedi, SB Long - Elife, 2020 - elifesciences.org
The calcium release-activated calcium channel Orai regulates Ca2+ entry into non-excitable
cells and is required for proper immune function. While the channel typically opens following …

Molecular basis of allosteric Orai1 channel activation by STIM1

PSW Yeung, M Yamashita… - The Journal of …, 2020 - Wiley Online Library
Store‐operated Ca2+ entry through Orai1 channels is a primary mechanism for Ca2+ entry
in many cells and mediates numerous cellular effector functions ranging from gene …

ORAI1 mutations with distinct channel gating defects in tubular aggregate myopathy

J Böhm, M Bulla, JE Urquhart, E Malfatti… - Human …, 2017 - Wiley Online Library
ABSTRACT Calcium (Ca2+) is a physiological key factor, and the precise modulation of free
cytosolic Ca2+ levels regulates multiple cellular functions. Store‐operated Ca2+ entry …

Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription

I Frischauf, M Litviňuková, R Schober, V Zayats… - Science …, 2017 - science.org
The channel Orai1 requires Ca2+ store depletion in the endoplasmic reticulum and an
interaction with the Ca2+ sensor STIM1 to mediate Ca2+ signaling. Alterations in Orai1 …

Orai2 Modulates Store-Operated Ca2+ Entry and Cell Cycle Progression in Breast Cancer Cells

J Sanchez-Collado, JJ Lopez, C Cantonero, I Jardin… - Cancers, 2021 - mdpi.com
Simple Summary Breast cancer shows a high heterogeneity which accounts for cancer
subtype aggressiveness. Store-operated calcium entry (SOCE) is significantly remodeled in …

Trpm4 in cancer—a new potential drug target

A Borgström, C Peinelt, P Stokłosa - Biomolecules, 2021 - mdpi.com
Transient receptor potential melastatin 4 (TRPM4) is widely expressed in various organs
and associated with cardiovascular and immune diseases. Lately, the interest in studies on …