Alzheimer's disease is a chronic and progressive brain neurodegenerative disease affecting
over 30 million people globally. Currently, no effective treatment is available due to multiple …

Neurodegenerative diseases represent nowadays one of the major health problems.
Despite the efforts made to unveil the mechanism leading to neurodegeneration, it is still not …

To obtain a multipotent framework that can target simultaneously COX-2, 5-LOX,
acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) to treat neuroinflammation …

Background Alzheimer's disease (AD) is a neurodegenerative disease caused by the
formation of amyloid-beta (Aβ) plaques and neurofibrillary tangles. Acetylcholinesterase …

Neuroinflammation and cholinergic deficit are key detrimental processes involved in
Alzheimer's disease. Hence, in the search for novel and effective treatment strategies, the …

'Acridine'along with its functional analogue 'Acridone'is the most privileged pharmacophore
in medicinal chemistry with diverse applications ranging from DNA intercalators …

Alzheimer's disease (AD) is a slowly progressive neurodegenerative disease
conceptualized as a continuous process, ranging from mild cognitive impairment (MCI), to …

Tacrine is a drug used in the treatment of Alzheimer's disease as a cognitive enhancer and
inhibitor of the enzyme acetylcholinesterase (AChE). However, its clinical application has …

Acetylcholinesterase is an important biochemical enzyme in that it controls acetylcholine-
mediated neuronal transmission in the central nervous system, contains a unique structure …

The discovery and development of multitarget-directed ligands (MTDLs) is a promising
strategy to find new therapeutic solutions for neurodegenerative diseases (NDs), in …