The local extension of cancer cells along nerves is a frequent clinical finding for various
tumours. Traditionally, nerve invasion was assumed to occur via the path of least resistance; …

Prion diseases are transmissible spongiform encephalopathies (TSEs), attributed to
conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer …

Caveolae were originally identified as ffask-shaped invaginations of the plasma membrane
in endothelial and epithelial cells (14). Prior to the development of biochemical methods for …

Our laboratory has demonstrated that 17β-estradiol (E2) enhances hippocampal memory
consolidation via rapid activation of multiple intracellular signaling cascades, including the …

The processing of amyloid precursor protein (APP) generates amyloid-β (Aβ) peptides 1–40
and 1–42. The latter is neurotoxic and its accumulation results in amyloid fibril formation and …

Caveolins (Cavs) are integrated plasma membrane proteins that are complex signaling
regulators with numerous partners and whose activity is highly dependent on cellular …

Caveolin-1 is an essential structural constituent of caveolae that has been implicated in
mitogenic signaling and oncogenesis. Caveolin-1 is down-regulated in oncogene …

Using confocal laser scanning and double immunogold electron microscopy, we
demonstrate that reggie-1 and-2 are colocalized in≤ 0.1-μm plasma membrane …

We looked for mutations in the caveolin-1 gene, encoding a critical molecule for membrane
signaling to cell growth, in 92 primary human breast cancers, and we report here the …

It has become widely accepted that along with its ability to directly regulate gene expression,
estradiol also influences cell signaling and brain function via rapid membrane-initiated …