Glaucoma is an optic neuropathy that is characterized by the progressive degeneration of
the optic nerve, leading to visual impairment. Glaucoma is the main cause of irreversible …

Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …

Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by a
slow, progressive, and multifactorial degeneration of retinal ganglion cells (RGCs) and their …

Importance Retinal ganglion cells endure significant metabolic stress in glaucoma but
maintain capacity to recover function. Nicotinamide, a precursor of NAD+, is low in serum of …

Mitochondrial dysfunction increases reactive oxygen species (ROS) production and when
this overwhelms the cellular antioxidant defences, oxidative stress ensues. Oxidative stress …

The microbiota is a dynamic ecosystem that plays a major role in the host health. Numerous
studies have reported that alterations in the intestinal microbiota (dysbiosis) may contribute …

Purpose.: To test whether a diet supplemented with coenzyme Q10 (CoQ 10) ameliorates
glutamate excitotoxicity and oxidative stress–mediated retinal ganglion cell (RGC) …

Oxidative phosphorylation (OXPHOS) drives ATP production by mitochondria, which are
dynamic organelles, constantly fusing and dividing to maintain kidney homoeostasis. In …

Retinal ganglion cells, the neurons that selectively die in glaucoma and other optic
neuropathies, are endowed with an exceedingly active metabolism and display a particular …

Coenzyme Q10 (CoQ10 or ubiquinone) is a mobile proton and electron carrier of the
mitochondrial respiratory chain with antioxidant properties widely used as an antiaging …