DNA methylation regulates many cellular processes, including embryonic development,
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …

Cancer is one of the deadliest diseases in the world causing record number of mortalities in
both developed and undeveloped countries. Despite a lot of advances and breakthroughs in …

Adenoid cystic carcinomas (ACCs) are among the most enigmatic of human malignancies.
These aggressive salivary gland cancers frequently recur and metastasize despite definitive …

Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is an essential regulator of
DNA methylation that is highly expressed in many cancers. Here, we use transgenic …

Many long noncoding RNAs (lncRNAs) are reported to be dysregulated in human cancers
and play critical roles in tumor development and progression. Furthermore, it has been …

Histone methylation occurs on both lysine and arginine residues, and its dynamic regulation
plays a critical role in chromatin biology. Here we identify the UHRF1 PHD finger (PHD …

Background: Tumor-associated macrophages (TAMs) and dysregulated tumor epigenetics
contribute to hepatocellular carcinoma (HCC) progression. However, the mechanistic …

BRCA1 is an important mediator of the DNA damage response, which promotes
homologous recombination (HR) and antagonizes 53BP1-dependent non-homologous end …

During S phase, the cooperation between the macromolecular complexes regulating DNA
synthesis, epigenetic information maintenance and DNA repair is advantageous for cells, as …

Clear cell renal cell carcinoma (ccRCC) is a heterogeneous tumor that the underlying
molecular mechanisms are largely unclear. This study aimed to elucidate the key candidate …