Cancer cells require a massive supply of nutrients, including sugars and amino acids—the
upregulation of transporters for each nutrient contributes to meet the demand. Distinct from …

The transport of amino acids in kidney and intestine is critical for the supply of amino acids to
all tissues and the homeostasis of plasma amino acid levels. This is illustrated by a number …

Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for severe acute respiratory
syndrome–coronavirus (SARS-CoV) and the new coronavirus (SARS-CoV-2) that is causing …

Relative to other neutral amino acid transporters, the expression levels of ASCT2 and LAT1,
are coordinately elevated in a wide spectrum of primary human cancers, suggesting that …

Glutamine together with glucose is essential for body's homeostasis. It is the most abundant
amino acid and is involved in many biosynthetic, regulatory and energy production …

Glucose and glutamine serve as the two primary carbon sources in proliferating cells, and
uptake of both nutrients is directed by growth factor signaling. Although either glucose or …

The small intestine mediates the absorption of amino acids after ingestion of protein and
sustains the supply of amino acids to all tissues. The small intestine is an important …

The kidneys integrate information from continuous systemic processes related to the
absorption, distribution, metabolism and excretion (ADME) of metabolites. To identify …

Indoleamine 2, 3-dioxygenase (INDO) and tryptophan 2, 3-dioxygenase (TDO) each
catalyze the first step in the kynurenine pathway of tryptophan metabolism. We describe the …

Over the last 50 yr, the study of intestinal peptide transport has rapidly evolved into a field
with exciting nutritional and biomedical applications. In this review, we describe from a …