The importance of antimicrobial resistance in medical mycology

NAR Gow, C Johnson, J Berman, AT Coste… - Nature …, 2022 - nature.com
Prior to the SARS-CoV-2 pandemic, antibiotic resistance was listed as the major global
health care priority. Some analyses, including the O'Neill report, have predicted that deaths …

Emerging Fungal Infections: from the Fields to the Clinic, Resistant Aspergillus fumigatus and Dermatophyte Species: a One Health Perspective on an Urgent Public …

A Langfeldt, JAW Gold, T Chiller - Current Clinical Microbiology Reports, 2022 - Springer
Abstract Purpose of Review For this review, we use a One Health approach to examine two
globally emerging public health threats related to antifungal drug resistance: triazole …

[PDF][PDF] Amphotericin B: A comprehensive overview of its clinical applications and toxicity management

I Karunarathna, U Ekanayake, K Gunawardana… - 2024 - researchgate.net
Amphotericin B deoxycholate, a key member of the polyene antifungal class, has been a
cornerstone in the treatment of invasive fungal infections for over five decades. Despite its …

[PDF][PDF] Amphotericin B: A critical review of its role in antifungal therapy and patient outcomes

I Karunarathna, U Ekanayake, K Gunawardana… - 2024 - researchgate.net
Amphotericin B deoxycholate, a key member of the polyene antifungal class, has been a
cornerstone in the treatment of invasive fungal infections for over five decades. Despite its …

[PDF][PDF] Amphotericin B and the management of refractory fungal infections: An expert review

I Karunarathna, U Ekanayake, K Gunawardana… - 2024 - researchgate.net
Amphotericin B deoxycholate, a key member of the polyene antifungal class, has been a
cornerstone in the treatment of invasive fungal infections for over five decades. Despite its …

Toxic eburicol accumulation drives the antifungal activity of azoles against Aspergillus fumigatus

H Elsaman, E Golubtsov, S Brazil, N Ng… - Nature …, 2024 - nature.com
Azole antifungals inhibit the sterol C14-demethylase (CYP51/Erg11) of the ergosterol
biosynthesis pathway. Here we show that the azole-induced synthesis of fungicidal cell wall …

Delineation of the Direct Contribution of Candida auris ERG11 Mutations to Clinical Triazole Resistance

JM Rybak, C Sharma, LA Doorley, KS Barker… - Microbiology …, 2021 - Am Soc Microbiol
Resistance to fluconazole is one of clinical characteristics most frequently challenging the
treatment of invasive Candida auris infections, and is observed among> 90% of all …

Mechanisms of triazole resistance in Aspergillus fumigatus

AV Nywening, JM Rybak, PD Rogers… - Environmental …, 2020 - Wiley Online Library
The ubiquitous fungal pathogen Aspergillus fumigatus is the primary cause of opportunistic
mould infections in humans. Aspergilli disseminate via asexual conidia passively travelling …

Citizen Science Surveillance of Triazole-Resistant Aspergillus fumigatus in United Kingdom Residential Garden Soils

JMG Shelton, R Collins, CB Uzzell… - Applied and …, 2022 - Am Soc Microbiol
Compost is an ecological niche for Aspergillus fumigatus due to its role as a decomposer of
organic matter and its ability to survive the high temperatures associated with the …

Application of antimicrobial, potential hazard and mitigation plans

SC Khoo, MS Goh, A Alias, V Luang-In, KW Chin… - Environmental …, 2022 - Elsevier
The tremendous rise in the consumption of antimicrobial products had aroused global
concerns, especially in the midst of pandemic COVID-19. Antimicrobial resistance has been …