Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

It has been one and a half centuries since Enrico Sertoli published the seminal discovery of
the testicular 'nurse cell', not only a key cell in the testis, but indeed one of the most amazing …

The functions of Sertoli cells in spermatogenesis have attracted much more attention
recently. Normal spermatogenesis depends on Sertoli cells, mainly due to their influence on …

Mammalian male germ cell development is a stepwise cell-fate transition process; however,
the full-term developmental profile of male germ cells remains undefined. Here, by …

Spermatogenesis is a complex, multistep process that maintains male fertility and is
sustained by rare germline stem cells. Spermatogenic progression begins with …

The production of spermatozoa relies on a pool of spermatogonial stem cells (SSCs), formed
in infancy from the differentiation of their precursor cells, the gonocytes. Throughout adult …

Male germ cell development depends on multiple biological events that combine epigenetic
reprogramming, cell cycle regulation, and cell migration in a spatio-temporal manner. Sertoli …

Retinoic acid (RA) directs the sequential, but distinct, programs of spermatogonial
differentiation and meiotic differentiation that are both essential for the generation of …

Androgens responsible for male sexual differentiation in utero are produced by Leydig cells
in the fetal testicular interstitium. Leydig cells rarely proliferate and, hence, rely on constant …

Sertoli cells regulate male germ cell proliferation and differentiation and are a critical
component of the spermatogonial stem cell (SSC) niche, where homeostasis is maintained …