Metallodrugs are unique: Opportunities and challenges of discovery and development
EJ Anthony, EM Bolitho, HE Bridgewater… - Chemical …, 2020 - pubs.rsc.org
Metals play vital roles in nutrients and medicines and provide chemical functionalities that
are not accessible to purely organic compounds. At least 10 metals are essential for human …
are not accessible to purely organic compounds. At least 10 metals are essential for human …
Visible-to-NIR-light activated release: from small molecules to nanomaterials
Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable)
protecting groups (PPGs), also known as caged or photocaged compounds, are used to …
protecting groups (PPGs), also known as caged or photocaged compounds, are used to …
An orally-administered nanotherapeutics with carbon monoxide supplying for inflammatory bowel disease therapy by scavenging oxidative stress and restoring gut …
X Zhang, Z Yuan, J Wu, Y He, G Lu, D Zhang, Y Zhao… - ACS …, 2023 - ACS Publications
Traditional drug-based treatments for inflammatory bowel disease (IBD) have significant
limitations due to their potential off-target systemic side-effects. Currently, there is a lack of …
limitations due to their potential off-target systemic side-effects. Currently, there is a lack of …
Excited-state intramolecular proton transfer-driven photon-gating for photoelectrochemical sensing of CO-releasing molecule-3
Y Gao, J Tang, Q Zhou, Z Yu, D Wu, D Tang - Analytical Chemistry, 2024 - ACS Publications
Different from prevalent approaches such as immunological recognition, complementary
base pairing, or enzymatic regulation in current photoelectrochemical (PEC) sensing, this …
base pairing, or enzymatic regulation in current photoelectrochemical (PEC) sensing, this …
Gas‐generating nanoplatforms: material chemistry, multifunctionality, and gas therapy
L Yu, P Hu, Y Chen - Advanced Materials, 2018 - Wiley Online Library
The fast advances of theranostic nanomedicine enable the rational design and construction
of diverse functional nanoplatforms for versatile biomedical applications, among which gas …
of diverse functional nanoplatforms for versatile biomedical applications, among which gas …
Click and release: bioorthogonal approaches to “on-demand” activation of prodrugs
Prodrug approaches represent an excellent solution to certain pharmaceutical issues
commonly encountered in the drug discovery and development process. Along this line, the …
commonly encountered in the drug discovery and development process. Along this line, the …
An all-in-one CO gas therapy-based hydrogel dressing with sustained insulin release, anti-oxidative stress, antibacterial, and anti-inflammatory capabilities for infected …
J Chen, D Chen, J Chen, T Shen, T Jin, B Zeng, L Li… - Acta biomaterialia, 2022 - Elsevier
To effectively treat diabetic wounds, the development of versatile medical dressings that can
long-term regulate blood glucose and highly effective anti-oxidative stress, antibacterial and …
long-term regulate blood glucose and highly effective anti-oxidative stress, antibacterial and …
Orchestrating nitric oxide and carbon monoxide signaling molecules for synergistic treatment of MRSA infections
L Gao, J Cheng, Z Shen, G Zhang… - Angewandte Chemie …, 2022 - Wiley Online Library
The local delivery of gaseous signaling molecules (GSMs) has shown promising therapeutic
potential. However, although GSMs have a subtle interplay in physiological and pathological …
potential. However, although GSMs have a subtle interplay in physiological and pathological …
X‐Ray‐triggered Carbon Monoxide and Manganese Dioxide Generation based on Scintillating Nanoparticles for Cascade Cancer Radiosensitization
Carbon monoxide (CO) is an endogenous signaling molecule with broad therapeutic effects.
Here, a multifunctional X‐ray‐triggered carbon monoxide (CO) and manganese dioxide …
Here, a multifunctional X‐ray‐triggered carbon monoxide (CO) and manganese dioxide …
Smart hydrogels–synthetic stimuli-responsive antitumor drug release systems
A Kasiński, M Zielińska-Pisklak, E Oledzka… - International journal …, 2020 - Taylor & Francis
Among modern drug formulations, stimuli-responsive hydrogels also called “smart
hydrogels” deserve a special attention. The basic feature of this system is the ability to …
hydrogels” deserve a special attention. The basic feature of this system is the ability to …