Predicting the risk of post-hepatectomy portal hypertension using a digital twin: A clinical proof of concept

N Golse, F Joly, P Combari, M Lewin, Q Nicolas… - Journal of …, 2021 - Elsevier
Background & Aims Despite improvements in medical and surgical techniques, post-
hepatectomy liver failure (PHLF) remains the leading cause of postoperative death. High …

Post-hepatectomy liver failure: A timeline centered review

M Bekheit, L Grundy, AKA Salih, P Bucur… - … & Pancreatic Diseases …, 2023 - Elsevier
Background Post-hepatectomy liver failure (PHLF) is a leading cause of postoperative
mortality after liver surgery. Due to its significant impact, it is imperative to understand the …

In silico modeling for the hepatic circulation and transport: From the liver organ to lobules

H Ho, S Means, S Safaei… - WIREs mechanisms of …, 2023 - Wiley Online Library
The function of the liver depends critically on its blood supply. Numerous in silico models
have been developed to study various aspects of the hepatic circulation, including not only …

A time-dependent non-Newtonian extension of a 1D blood flow model

AR Ghigo, PY Lagree, JM Fullana - Journal of Non-Newtonian Fluid …, 2018 - Elsevier
Blood pulsatility, aneurysms, stenoses and general low shear stress hemodynamics
enhance non-Newtonian blood effects which generate local changes in the space-time …

Hierarchical modeling of the liver vascular system

AM Torres Rojas, S Lorente, M Hautefeuille… - Frontiers in …, 2021 - frontiersin.org
The liver plays a key role in the metabolic homeostasis of the whole organism. To carry out
its functions, it is endowed with a peculiar circulatory system, made of three main dendritic …

Computational analysis of one-dimensional models for simulation of blood flow in vascular networks

GV Krivovichev - Journal of Computational Science, 2022 - Elsevier
The paper is devoted to the comparison of one-dimensional models, used for the simulation
of blood flow in elastic vessels. The inviscid, Newtonian, and non-Newtonian models of …

Global sensitivity analysis of hepatic venous pressure gradient (HVPG) measurement with a stochastic computational model of the hepatic circulation

T Wang, F Liang, Z Zhou, X Qi - Computers in Biology and Medicine, 2018 - Elsevier
Hepatic venous pressure gradient (HVPG) is a widely employed surrogate of portal pressure
gradient (PPG) in the diagnosis of portal hypertension (PHT). However, little is known about …

Digital twin demonstrates significance of biomechanical growth control in liver regeneration after partial hepatectomy

S Hoehme, S Hammad, J Boettger, B Begher-Tibbe… - Iscience, 2023 - cell.com
Partial liver removal is an important therapy option for liver cancer. In most patients within a
few weeks, the liver is able to fully regenerate. In some patients, however, regeneration fails …

A computational model of the hepatic circulation applied to analyze the sensitivity of hepatic venous pressure gradient (HVPG) in liver cirrhosis

T Wang, F Liang, Z Zhou, L Shi - Journal of Biomechanics, 2017 - Elsevier
Measurement of hepatic venous pressure gradient (HVPG) is currently widely adopted to
provide an estimate of portal pressure gradient (PPG) in the diagnosis and treatment of …

Partial hepatectomy hemodynamics changes: Experimental data explained by closed-loop lumped modeling

C Audebert, M Bekheit, P Bucur, E Vibert… - Journal of …, 2017 - Elsevier
The liver function may be degraded after partial liver ablation surgery. Adverse liver
hemodynamics have been shown to be associated to liver failure. The link between these …