The past decade has witnessed exponentially growing interest in the lateral habenula (LHb)
owing to new discoveries relating to its critical role in regulating negatively motivated …

Aversive motivation plays a prominent role in driving individuals to exert cognitive control.
However, the complexity of behavioral responses attributed to aversive incentives creates …

Major depressive disorder ranks as a major burden of disease worldwide, yet the current
antidepressant medications are limited by frequent non-responsiveness and significant side …

Stress management is necessary for vertebrate survival. Chronic stress drives depression by
excitation of the lateral habenula (LHb), which silences dopaminergic neurons in the ventral …

The scaffolding A-kinase anchoring protein 150 (AKAP150) is critically involved in kinase
and phosphatase regulation of synaptic transmission/plasticity, and neuronal excitability …

Reinforcement, reward, and aversion are fundamental processes for guiding appropriate
behaviors. Longstanding theories have pointed to dopaminergic neurons of the ventral …

The lateral habenula (LHb) is an epithalamic brain region associated with value-based
decision making and stress evasion through its modulation of dopamine (DA)-mediated …

The lateral hypothalamic area (LHA) plays a pivotal role in regulating consciousness
transition, in which orexinergic neurons, GABAergic neurons, and melanin-concentrating …

Resilience means “the ability to withstand or recover quickly in the face of adversity”.
Elucidating the neural and molecular mechanisms underlying stress resilience will facilitate …

Affective disorders including depression (characterized by reduced motivation, social
withdrawal, and anhedonia), anxiety, and irritability are frequently reported as long-term …