The secretion profile of mesenchymal stem cells and potential applications in treating human diseases

Y Han, J Yang, J Fang, Y Zhou, E Candi… - … and Targeted Therapy, 2022 - nature.com
Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-
renewal potentials. MSCs-based therapies have been widely utilized for the treatment of …

Mesenchymal stromal/stem cells in regenerative medicine and tissue engineering

REB Fitzsimmons, MS Mazurek, A Soos… - Stem cells …, 2018 - Wiley Online Library
As a result of over five decades of investigation, mesenchymal stromal/stem cells (MSCs)
have emerged as a versatile and frequently utilized cell source in the fields of regenerative …

Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications

Y Wang, X Chen, W Cao, Y Shi - Nature immunology, 2014 - nature.com
Mesenchymal stem cells (MSCs) are multipotent stromal cells that exist in many tissues and
are capable of differentiating into several different cell types. Exogenously administered …

Mesenchymal stem cells: immune evasive, not immune privileged

JA Ankrum, JF Ong, JM Karp - Nature biotechnology, 2014 - nature.com
The diverse immunomodulatory properties of mesenchymal stem/stromal cells (MSCs) may
be exploited for treatment of a multitude of inflammatory conditions. MSCs have long been …

Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets

Y Shi, L Du, L Lin, Y Wang - Nature reviews Drug discovery, 2017 - nature.com
Mesenchymal stem cells, also known as mesenchymal stromal cells (MSCs), exist in many
tissues and are known to actively migrate to sites of tissue injury, where they participate in …

Immunobiology of mesenchymal stem cells

S Ma, N Xie, W Li, B Yuan, Y Shi, Y Wang - Cell Death & Differentiation, 2014 - nature.com
Mesenchymal stem cells (MSCs) can be isolated from almost all tissues and effectively
expanded in vitro. Although their true in situ properties and biological functions remain to be …

Single‐cell transcriptome atlas of human mesenchymal stem cells exploring cellular heterogeneity

Z Wang, C Chai, R Wang, Y Feng… - Clinical and …, 2021 - Wiley Online Library
Background The heterogeneity of mesenchymal stem cells (MSCs) is poorly understood,
thus limiting clinical application and basic research reproducibility. Advanced single‐cell …

Same or not the same? Comparison of adipose tissue-derived versus bone marrow-derived mesenchymal stem and stromal cells

M Strioga, S Viswanathan, A Darinskas… - Stem cells and …, 2012 - liebertpub.com
Mesenchymal stem/stromal cells (MSCs) comprise a heterogeneous population of cells with
multilineage differentiation potential, the ability to modulate oxidative stress, and secrete …

Immunosuppressive properties of mesenchymal stem cells: advances and applications

MP De Miguel, S Fuentes-Julian… - Current molecular …, 2012 - ingentaconnect.com
Mesenchymal stem cells (MSCs) have been isolated from a variety of tissues, such as bone
marrow, skeletal muscle, dental pulp, bone, umbilical cord and adipose tissue. MSCs are …

Immunological characterization of multipotent mesenchymal stromal cells—The International Society for Cellular Therapy (ISCT) working proposal

M Krampera, J Galipeau, Y Shi, K Tarte, L Sensebe - Cytotherapy, 2013 - Elsevier
Cultured mesenchymal stromal cells (MSCs) possess immune regulatory properties and are
already used for clinical purposes, although preclinical data (both in vitro and in vivo in …