Current directions in tau research: Highlights from Tau 2020
Studies supporting a strong association between tau deposition and neuronal loss,
neurodegeneration, and cognitive decline have heightened the allure of tau and tau‐related …
neurodegeneration, and cognitive decline have heightened the allure of tau and tau‐related …
Functional regulatory variants implicate distinct transcriptional networks in dementia
Predicting the function of noncoding variation is a major challenge in modern genetics. In
this study, we used massively parallel reporter assays to screen 5706 variants identified …
this study, we used massively parallel reporter assays to screen 5706 variants identified …
Cross-regional homeostatic and reactive glial signatures in multiple sclerosis
T Trobisch, A Zulji, NA Stevens, S Schwarz… - Acta …, 2022 - Springer
Multiple sclerosis (MS) is a multifocal and progressive inflammatory disease of the central
nervous system (CNS). However, the compartmentalized pathology of the disease affecting …
nervous system (CNS). However, the compartmentalized pathology of the disease affecting …
The three-dimensional landscape of cortical chromatin accessibility in Alzheimer's disease
To characterize the dysregulation of chromatin accessibility in Alzheimer's disease (AD), we
generated 636 ATAC-seq libraries from neuronal and nonneuronal nuclei isolated from the …
generated 636 ATAC-seq libraries from neuronal and nonneuronal nuclei isolated from the …
Navigating the ALS Genetic Labyrinth: The Role of MAPT Haplotypes
I Tourtourikov, K Dabchev, T Todorov, T Angelov… - Genes, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by wide
clinical and biological heterogeneity, with a large proportion of ALS patients also exhibiting …
clinical and biological heterogeneity, with a large proportion of ALS patients also exhibiting …