Immunoporosis: role of innate immune cells in osteoporosis

Y Saxena, S Routh, A Mukhopadhaya - Frontiers in immunology, 2021 - frontiersin.org
Osteoporosis or porous bone disorder is the result of an imbalance in an otherwise highly
balanced physiological process known as 'bone remodeling'. The immune system is …

[HTML][HTML] Targeting proteostasis network in osteoporosis: pathological mechanisms and therapeutic implications

C Ma, R Yu, J Li, J Chao, P Liu - Ageing Research Reviews, 2023 - Elsevier
As the most common bone disease, osteoporosis (OP) increases bone fragility and makes
patients more vulnerable to the threat of osteoporotic fractures. With the ageing population in …

[HTML][HTML] Black phosphorus biomaterials for photo-controlled bone tissue engineering

L Tan, M Li, Z Luo, K Cai, Y Hu - Composites Part B: Engineering, 2022 - Elsevier
Over the past decades, black phosphorus (BP) emerges as an effective photothermal
material with clinically favorable biocompatibility and biodegradation that receives broad …

Multi-omics data integration for identifying osteoporosis biomarkers and their biological interaction and causal mechanisms

C Qiu, F Yu, K Su, Q Zhao, L Zhang, C Xu, W Hu… - Iscience, 2020 - cell.com
Osteoporosis is characterized by low bone mineral density (BMD). The advancement of high-
throughput technologies and integrative approaches provided an opportunity for …

Endocrine, Metabolic, and Immune Pathogenesis of Postmenopausal Osteoporosis. Is there a Therapeutic Role in Natural Products?

G Lisco, D Triggiani, VA Giagulli… - … Metabolic & Immune …, 2023 - ingentaconnect.com
Background: Bone health relies on the equilibrium between resorption and new bone
generation. Postmenopausal osteoporosis depends on estrogen deficiency which favorite …

Inhibition of C5AR1 impairs osteoclast mobilization and prevents bone loss

C Pimenta-Lopes, C Sánchez-de-Diego, A Deber… - Molecular Therapy, 2023 - cell.com
Age-related and chemotherapy-induced bone loss depends on cellular senescence and the
cell secretory phenotype. However, the factors secreted in the senescent microenvironment …

Proteomic changes of osteoclast differentiation in rheumatoid and psoriatic arthritis reveal functional differences

OT Kovács, E Tóth, O Ozohanics… - Frontiers in …, 2022 - frontiersin.org
Background Osteoclasts play a crucial role in the maintenance, repair, and remodeling of
bones of the adult vertebral skeleton due to their bone resorption capability. Rheumatoid …

MAP Kinase driven actomyosin rearrangement is a crucial regulator of monocyte to macrophage differentiation

A Bhattacharya, P Ghosh, R Prasad, A Ghosh, K Das… - Cellular signalling, 2020 - Elsevier
Rearrangement of actin cytoskeleton correlates significantly with the immune responses as
the perturbation of cytoskeletal dynamics leads to many immune deficiencies. Mechanistic …

[HTML][HTML] An updated overview of the search for biomarkers of osteoporosis based on human proteomics

XY Wang, RZ Zhang, YK Wang, S Pan, SM Yun… - Journal of Orthopaedic …, 2024 - Elsevier
Osteoporosis is a chronic metabolic disease that increases bone fragility and, leads to
severe osteoporotic fractures. In recent years, the use of high-throughput omics to explore …

[HTML][HTML] Proteomic Biomarkers Associated with Low Bone Mineral Density: A Systematic Review

A Becerra-Cervera, AD Argoty-Pantoja… - International Journal of …, 2024 - mdpi.com
Osteoporosis is a globally relevant public health issue. Our study aimed to summarize the
knowledge on the proteomic biomarkers for low bone mineral density over the last years. We …