Abstract Purpose of Review Despite advances in orthopedics, there remains a need for
therapeutics to hasten fracture healing. However, little focus is given to the role the nervous …

Background Osteosarcopenia is a syndrome coexisting sarcopenia and osteopenia/
osteoporosis, with a high fracture risk. Recently, skeletal muscle and bone have been …

The neuronal engagement of the peripheral nerve system plays a crucial role in regulating
fracture healing, but how to modulate the neuronal activity to enhance fracture healing …

Background Osteogenesis and angiogenesis are important for bone fracture healing. Irisin is
a muscle-derived monokine that is associated with bone formation. Methods To demonstrate …

Abstract Purpose of Review Fractures are a prominent form of traumatic injury and shall
continue to be for the foreseeable future. While the inflammatory response and the cells of …

Abstract Purpose of Review The traditionally understated role of neural regulation in fracture
healing is gaining prominence, as recent findings underscore the peripheral nervous …

Although skeletal muscle has a high potential for self-repair, volumetric muscle loss can
result in impairment beyond the endogenous regenerative capacity. There is a clinical need …

Abstract Purpose of Review The identity and functional roles of stem cell population (s) that
contribute to fracture repair remains unclear. This review provides a brief history of …

The musculoskeletal system has an integral role throughout life, including structural support
to the body, protection, and allowing a range of fine to complex movements for daily living to …

Although the functions of the peripheral nervous system in whole body homeostasis and
sensation have been understood for many years, recent investigation has uncovered new …