Metabolic pathways involved in lactate metabolism are important to understand the
physiological response to exercise and the pathogenesis of prevalent diseases such as …

A review of the typical clinical course, diagnosis and treatment of acetaminophen toxicity is
provided. For an acute overdose, most adults must ingest about 12 g or more …

Drug-induced liver injury (DILI) is an important clinical problem, which has received more
attention in recent decades. It can be induced by small chemical molecules, biological …

Idiosyncratic drug-induced liver injury (DILI) is a rare disease that develops independently of
drug dose, route, or duration of administration. Furthermore, idiosyncratic DILI is not a single …

The low incidence of idiosyncratic drug-induced liver injury (DILI), together with the lack of a
reliable diagnostic biomarker and robust preclinical and in vitro toxicology test systems for …

Drug-induced liver injury (DILI) has become a major topic in the field of Hepatology and
Gastroenterology. DILI can be clinically divided into three phenotypes: hepatocytic …

To achieve sensitive and specific mechanism-based prediction of drug toxicity, the tools of
systems pharmacology will be integrated using structured ontological approaches, analytics …

An increasing number of commonly prescribed drugs are known to interfere with
mitochondrial function, which is associated with almost half of all Food and Drug …

Xenobiotics, of which many are toxic, may enter the human body through multiple routes.
Excessive human exposure to xenobiotics may exceed the body's capacity to defend against …

Herbal and dietary supplements (HDS)-induced liver injury has been a great concern all
over the world. Polygonum multiflorum Thunb., a well-known Chinese herbal medicine, is …