Most cases of serotonin toxicity are provoked by therapeutic doses of a combination of two
or more serotonergic drugs, defined as drugs affecting the serotonin neurotransmitter …

Drugs may cause serotonin toxicity by a number of different mechanisms including inhibition
of serotonin uptake and metabolism, increased serotonin synthesis and release, activation …

CHRONIC pain is a complex and subjective experience reflecting interactions of sensory,
affective, cognitive, behavioral, and social factors. 1 The complexity of chronic pain …

Opioid analgesics have an established role in the management of postoperative pain and
cancer pain, and are gaining acceptance for the management of moderate to severe chronic …

The clinical manifestation of drug-induced abnormalities in thermoregulation occurs across
a variety of drug mechanisms. The aim of this chapter is to review two of the most common …

Serotonin syndrome is associated with use of certain street drugs, including
methamphetamine, cocaine, and ecstasy. We describe a case of a woman who developed …

Purpose To report a case of serotonin toxicity, presenting in the postoperative period,
caused by an interaction between paroxetine (a selective serotonin reuptake inhibitor, SSRI) …

Background Opioids are the most frequently used drugs to treat pain in cancer patients. In
some patients, however, opioids can cause adverse effects and drug–drug interactions. No …

Background Serotonin toxicity is a common cause of drug-induced altered mental status.
However, data on the causes of serotonin toxicity, symptomatology, complications, and rate …

Abstract The serotonin (5-hydroxtryptamine, 5-HT) system plays a role in analgesia and
emesis. The aim of this study was to test whether opioids or ketamine inhibit the human 5-HT …