Chronic pain is sustained, in part, through the intricate process of central sensitization (CS),
marked by maladaptive neuroplasticity and neuronal hyperexcitability within central pain …

Background: Understanding the clinical course of low back pain is essential to informing
treatment recommendations and patient stratification. Our aim was to update our previous …

Predicting the development of chronic low back pain (LBP) at the time of an acute episode
remains challenging. The Understanding persistent Pain Where it ResiDes study aimed to …

Musculoskeletal pain is an extensive societal challenge, due to the large population
affected, an increased expected life span, and the lack of efficient prevention and treatment …

Despite being a first-line treatment recommendation, there is uncertainly for how exercise
helps people with chronic low back pain. We designed this study to examine how exercise …

The prolonged duration of chronic low back pain (cLBP) inevitably leads to changes in the
cognitive, attentional, sensory and emotional processing brain regions. Currently, it remains …

Background Chronic pain involves communication between neural and immune systems.
Recent data suggest localization of glial (brain immune cells) activation to the sensorimotor …

Primary chronic pain is a major contributor to disability worldwide, with an estimated
prevalence of 20–33% of the world's population. The high socio-economic impact of …

Introduction Chronic lower back pain (cLBP), frequently attributed to lumbar disk herniation
(LDH), imposes substantial limitations on daily activities. Despite its prevalence, the neural …

Background: While low back pain (LBP) is the leading cause of disability worldwide, its
clinical objective assessment is currently limited. Part of this syndrome arises from the …