[HTML][HTML] De-escalation of axillary irradiation for early breast cancer–Has the time come?

E Senkus, MJ Cardoso, O Kaidar-Person… - Cancer Treatment …, 2021 - Elsevier
Introduction of sentinel lymph node biopsy, initially in clinically node-negative and
subsequently in patients presenting with involved axilla and downstaged by primary …

De-escalation of radiotherapy after primary chemotherapy in cT1–2N1 breast cancer (RAPCHEM; BOOG 2010–03): 5-year follow-up results of a Dutch, prospective …

SR de Wild, L de Munck, JM Simons, J Verloop… - The Lancet …, 2022 - thelancet.com
Background Primary chemotherapy in breast cancer poses a dilemma with regard to
adjuvant locoregional radiotherapy, as guidelines for locoregional radiotherapy were …

Breast cancer biology: clinical implications for breast radiation therapy

JK Horton, R Jagsi, WA Woodward, A Ho - International Journal of …, 2018 - Elsevier
Historically, prognosis and treatment decision making for breast cancer patients have been
dictated by the anatomic extent of tumor spread. However, in recent years,“breast cancer” …

ATR inhibition is a promising radiosensitizing strategy for triple-negative breast cancer

X Tu, MM Kahila, Q Zhou, J Yu, KR Kalari, L Wang… - Molecular cancer …, 2018 - AACR
Triple-negative breast cancer (TNBC) is characterized by elevated locoregional recurrence
risk despite aggressive local therapies. New tumor-specific radiosensitizers are needed. We …

Tumor biology and response to chemotherapy impact breast cancer-specific survival in node-positive breast cancer patients treated with neoadjuvant chemotherapy …

JC Boughey, KV Ballman, LM McCall… - Annals of …, 2017 - journals.lww.com
Background: Women with node-positive breast cancer are at high risk for recurrence. We
evaluate the impact of approximated tumor subtype and response to chemotherapy on long …

[HTML][HTML] Disease-free and overall survival after neoadjuvant chemotherapy in breast cancer: breast-conserving surgery compared to mastectomy in a large single …

JM Simons, JG Jacobs, JP Roijers, MA Beek… - Breast Cancer Research …, 2021 - Springer
Purpose The extended role of breast-conserving surgery (BCS) in the neoadjuvant setting
may raise concerns on the oncologic safety of BCS compared to mastectomy. This study …

[HTML][HTML] Impact of age on pathological complete response and locoregional recurrence in locally advanced breast cancer after neoadjuvant chemotherapy

HH Chou, WL Kuo, CC Yu, HP Tsai, SC Shen, CH Chu… - Biomedical journal, 2019 - Elsevier
Background Neoadjuvant chemotherapy (NAC) is the standard approach for downstaging of
locally advanced breast cancer and can improve breast conservation rates. A pathological …

Patterns of axillary management in stages 2 and 3 hormone receptor-positive breast cancer by initial treatment approach

A Weiss, S Wong, M Golshan, RA Freedman… - Annals of surgical …, 2019 - Springer
Background Data regarding axillary management after neoadjuvant endocrine therapy
(NET) are lacking. This study examined axillary management of hormone receptor-positive …

[HTML][HTML] B7-H4 overexpression contributes to poor prognosis and drug-resistance in triple-negative breast cancer

L Wang, C Yang, X Liu, L Wang, F Kang - Cancer Cell International, 2018 - Springer
Background The expression of the immunoregulatory protein B7-H4 has been reported in
many types of cancer, including breast cancer. However, its role in triple-negative breast …

[HTML][HTML] Locoregional recurrence risk after neoadjuvant chemotherapy: A pooled analysis of nine prospective neoadjuvant breast cancer trials

G Werutsky, M Untch, C Hanusch, PA Fasching… - European Journal of …, 2020 - Elsevier
Aim This pooled analysis aimed to evaluate locoregional recurrence (LRR) rates of breast
cancer (BC) after neoadjuvant chemotherapy (NACT) and to identify independent LRR …