Haematopoietic stem cells (HSCs) in mouse bone marrow are located in specialized niches
as single cells. During homeostasis, signals from this environment keep some HSCs …

Drug resistance has profoundly limited the success of cancer treatment, driving relapse,
metastasis, and mortality. Nearly all anticancer drugs and even novel immunotherapies …

Classical BCR-ABL–negative myeloproliferative neoplasms (MPNs) are clonal disorders of
hematopoietic stem cells (HSCs) caused mainly by recurrent mutations in genes encoding …

Cancer stem cells (CSC s) generate transient‐amplifying cells and thereby contribute to
cancer propagation. A fuller understanding of the biological features of CSC s is expected to …

Targeted therapies of chronic myeloid leukemia (CML) using tyrosine kinase inhibitors (TKI)
have profoundly changed the natural history of the disease with a major impact on survival …

The objective of this paper is to give a review of the main works dealing with mathematical
modeling of blood cell formation, disorders and treatments within the past fifty years. From …

Molecular response to imatinib (IM) in chronic myeloid leukemia (CML) is associated with a
biphasic but heterogeneous decline of BCR-ABL transcript levels. We analyzed this …

Chronic myeloid leukemia (CML) is a blood disease that disrupts normal function of the
hematopoietic system. Despite the great progress made in terms of molecular therapies for …

Background The Cancer Stem Cell (CSC) hypothesis has gained credibility within the
cancer research community. According to this hypothesis, a small subpopulation of cells …

Chronic myeloid leukemia (CML) is the first human malignancy to be successfully treated
with a small molecule inhibitor, imatinib, targeting a mutant oncoprotein (BCR-ABL). Despite …