The lipid bilayer component of biological membranes is important for the distribution,
organization, and function of bilayer-spanning proteins. This regulation is due to both …

A polymer chain of N atoms enjoys 3N-6 internal degrees of freedom, which gives rise to
infinitely many conformations. Even a simple model of N) 100 atoms where bond lengths …

Living cells regulate the activity of their ion channels through a process known as gating. To
open the pore, protein conformational changes must occur within a channel's membrane …

Interconversion between conductive and non-conductive forms of the K+ channel selectivity
filter underlies a variety of gating events, from flicker transitions (at the microsecond …

Mechanosensitive channels act as membrane-embedded mechano-electrical switches,
opening a large water-filled pore in response to lipid bilayer deformations. This process is …

Electron paramagnetic resonance (EPR) spectroscopy provides a variety of tools to study
structures and structural changes of large biomolecules or complexes thereof. In order to …

The mechanosensitive channel of small conductance (MscS) responds both to stretching of
the cell membrane and to membrane depolarization. The crystal structure at 3.9 angstroms …

Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …

1. Introduction 172. Dynamics of many-body systems 192.1 Effective dynamics of reduced
systems 212.2 The constraint of thermodynamic equilibrium 242.3 Mean-field theories 253 …

Site-directed spin labeling is a general method for investigating structure and conformational
switching in soluble and membrane proteins. It will also be an important tool for exploring …