The complex and multifaceted nature of Alzheimer's disease has brought about a pressing
demand to develop ligands targeting multiple pathways to combat its outrageous …

Background: Alzheimer's disease (AD) is an advanced and irreversible degenerative
disease of the brain, recognized as the key reason for dementia among elderly people. The …

In continuation of our previous study to identify multitarget inhibitors of cholinesterases
(ChEs) and monoamine oxidase (MAOs) isoforms, we synthesized and evaluated 2 …

Caffeine is one of the privileged natural products that shows numerous effects on the central
nervous system. Herein, thirty-one caffeine-based amide derivatives were synthesized and …

Colchicine, one of the oldest anti-inflammatory natural products still used clinically, inhibits
NF-κB signaling and NLRP3 inflammasome activation. Despite its cytotoxicity and narrow …

Natural products have significantly contributed to drug discovery for neurodegenerative
diseases. Caffeine is one of the well‐known central nervous system (CNS)‐active natural …

A small library of molecules combining indolizine and N-alkyl pyridinium was synthesized
and evaluated in a multi-target-directed-ligand strategy for Alzheimer's disease (AD) …

The N‐benzyl piperidine (N‐BP) structural motif is commonly employed in drug discovery
due to its structural flexibility and three‐dimensional nature. Medicinal chemists frequently …

Coumarin is a naturally occurring bioactive pharmacophore with wide occurrence among
central nervous system (CNS)-active small molecules. 8-Acetylcoumarin, one of the natural …

In this study, a series of new benzimidazole/1, 3, 5-triazine-2, 4-diamine hybrid derivatives
(9a–9l) were designed and synthesized. The potential multi-target profiles of these …