The retinal pigment epithelium: an important player of retinal disorders and regeneration

C Chiba - Experimental eye research, 2014 - Elsevier
The retinal pigment epithelium (RPE) is a partner of the neural retina and is indispensable
for vision. In humans, proliferation and transformation (cell-type switching) of RPE cells after …

[HTML][HTML] Mechanisms of epithelial-mesenchymal transition in proliferative vitreoretinopathy

S Yang, H Li, M Li, F Wang - Discovery medicine, 2015 - discoverymedicine.com
Proliferative vitreoretinopathy (PVR) is a blinding disease characterized by the formation of
epiretinal membranes through the wound repair process. Though the mechanisms of PVR …

[HTML][HTML] The FOS transcription factor family differentially controls trophoblast migration and invasion

SJ Renaud, K Kubota, MAK Rumi, MJ Soares - Journal of Biological …, 2014 - ASBMB
Extravillous trophoblast invasion is a fundamental component of human placentation.
Invading trophoblast cells promote blood flow to the conceptus by actively remodeling the …

[HTML][HTML] Mature peripheral RPE cells have an intrinsic capacity to proliferate; a potential regulatory mechanism for age-related cell loss

I Kokkinopoulos, G Shahabi, A Colman, G Jeffery - PloS one, 2011 - journals.plos.org
Background Mammalian peripheral retinal pigmented epithelium (RPE) cells proliferate
throughout life, while central cells are senescent. It is thought that some peripheral cells …

Cellular trafficking of low molecular weight heparin incorporated in layered double hydroxide nanoparticles in rat vascular smooth muscle cells

Z Gu, BE Rolfe, AC Thomas, JH Campbell, GQM Lu… - Biomaterials, 2011 - Elsevier
This paper reports a clear elucidation of the pathway for the cellular delivery of layered
double hydroxide (LDH) nanoparticles intercalated with anti-restenotic low molecular weight …

Thrombin promotes actin stress fiber formation in RPE through Rho/ROCK‐mediated MLC phosphorylation

AY Ruiz‐Loredo, E López… - Journal of cellular …, 2011 - Wiley Online Library
The retinal pigment epithelium (RPE) forms the outer blood–retina barrier (BRB). Most
retinal diseases involve BRB breakdown, whereupon thrombin contained in serum directly …

[HTML][HTML] Thrombin induces epithelial-mesenchymal transition and collagen production by retinal pigment epithelial cells via autocrine PDGF-receptor signaling

J Bastiaans, JC van Meurs… - … & visual science, 2013 - iovs.arvojournals.org
Purpose.: De-differentiation of RPE cells into mesenchymal cells (epithelial-mesenchymal
transition; EMT) and associated collagen production contributes to development of …

ERK1/2-dependent activation of mTOR/mTORC1/p70S6K regulates thrombin-induced RPE cell proliferation

A Parrales, E López, I Lee-Rivera, AM López-Colomé - Cellular Signalling, 2013 - Elsevier
Epithelial–mesenchymal transition (EMT), proliferation and migration of RPE cells
characterize the development of proliferative vitreoretinopathy (PVR) and other fibro …

VEGF/VEGFR2 signaling regulates germ cell proliferation in vitro and promotes mouse testicular regeneration in vivo

R Tian, S Yang, Y Zhu, S Zou, P Li, J Wang, Z Zhu… - Cells Tissues …, 2016 - karger.com
Vascular endothelial growth factor (VEGF) plays fundamental roles in testicular
development; however, its function on testicular regeneration remains unknown. The …

Apo-and holo-lactoferrin stimulate proliferation of mouse crypt cells but through different cellular signaling pathways

R Jiang, B Lönnerdal - The International Journal of Biochemistry & Cell …, 2012 - Elsevier
Lactoferrin (Lf), an iron-binding glycoprotein in human milk, plays an important role in
intestinal epithelial cell proliferation, but the underlying molecular mechanisms remain …